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Pulmonary hypertension is a rare and severe disease, affecting a young population. Survival is very poor and has been closely related to right ventricular dysfunction. Current prognostic equations rely mostly on right heart catheterization data. The identification of simple echocardiographic prognostic factor is urgently needed. It could help identifying with a non invasive method, high risk patients who could benefit from an intensive specific therapy. 3D right ventricular imaging is a new echocardiographic tool which provides RV volumic analysis, RV ejection fraction, overcoming the classical limits of 2D ultrasound.
The aim of this study is to validate a new software for 3D analysis of the right ventricle and assess its prognostic role in pulmonary hypertension.
To do so, the investigators will realize a prospective monocentric longitudinal cohort study, including 100 pulmonary hypertension patients. Echocardiographic data will be collected at baseline and after 6 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case | Echocardiographic data : 3D right ventricular imaging on 100 pulmonary hypertension patients at Baseline and after six months |
| |
| Control | Echocardiographic data : 3D right ventricular Imaging on 50 patients without pulmonary hypertension only at baseline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3D right ventricular imaging echocardiographic | Device | Echocardiographic data (3D right ventricular imaging echocardiographic) will be collected at baseline and after 6months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of death from any cause | Description of the number of death during the study | Baseline to 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Hospitalisation | Description of the number of hospitalisation for worsening of pulmonary arterial hypertension | Baseline to 24 months |
| 3D right ventricular imaging echocardiographic | Analyse the data of 3D right ventricular (RV), ejection fraction, RV telediastolic and telesystolic volume, 3D RV area strain (%) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with pulmonary hypertension diagnosed
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| Name | Affiliation | Role |
|---|---|---|
| PAMELA MOCERI, MD | Centre Hospitalier Universitaire de Nice | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Pasteur - Chu Nice | Nice | 06000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36265185 | Derived | Moceri P, Duchateau N, Baudouy D, Squara F, Bun SS, Ferrari E, Sermesant M. Additional prognostic value of echocardiographic follow-up in pulmonary hypertension-role of 3D right ventricular area strain. Eur Heart J Cardiovasc Imaging. 2022 Oct 20;23(11):1562-1572. doi: 10.1093/ehjci/jeab240. |
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| ID | Term |
|---|---|
| D000081029 | Pulmonary Arterial Hypertension |
| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| Baseline and 6 months |