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A significant weight gain and obesity are observed for most patients with narcolepsy, mainly at the beginning of the disease and narcolepsy in young children. There is no specific study on the population and the consequences of overweight in the lives of these long-term patients. Narcoleptic patients gain weight significantly at the onset of their illness. It is also known that weight gain is not related to the treatment of narcolepsy. The etiology of obesity in narcoleptic patients is not established. Several assumptions were made (physical activity, leptin diet, metabolism). The reason and the pathophysiology of overweight and obesity in this population therefore remain unclear.
In this study, potential change in the total metabolism (24h) for narcoleptic children that could explain their tendency to obesity will be assessed ?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Narcoleptic patients | Other |
| |
| hypersomnic patients | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep and metabolism assessment | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Determination of the metabolism at home | Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at home (15 days including scholar and non-scholar days). | 15 days |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of the metabolism at hospital | Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at hospital over 24 hours. | 18 days |
| Basal energy expenditure |
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Inclusion Criteria:
NARCOLEPTIC PATIENTS
HYPERSOMNIC PATIENTS
Exclusion Criteria:
NARCOLEPTIC PATIENTS
HYPERSOMNIC PATIENTS
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service d'Exploration et pathologie du sommeil, Hôpital Femme Mère Enfant | Bron | 69677 | France |
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| ID | Term |
|---|---|
| D009290 | Narcolepsy |
| ID | Term |
|---|---|
| D006970 | Disorders of Excessive Somnolence |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
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| ID | Term |
|---|---|
| D012890 | Sleep |
| ID | Term |
|---|---|
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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The basal metabolism (MET) measured by accelerometer (Actical, BodyMedia SW Actiheart) will be compared to the values of energy expenditure (kcal) measured by indirect calorimetry fasting. |
| 18 days |
| Energy expenditure and diet-induced thermogenesis | Energy expenditure (kcal) measured by indirect calorimetry after lunch (with counting calories ingested). | 18 days |
| Sympathetic activity | Estimated from IBI (Interbeat Interval) measured by Actiheart. | 18 days |
| Food intake | Caloric intake evaluation (kcal per day) during hospitalization (food intake recording) and at home during three days ( two days during the week and one day during the week-end) evaluated by questionnary. | 18 days |
| Fasting peptide YY | 18 days |
| Body weight | bodyweight (kg) | 18 days |
| Body height | Body height (cm) | 18 days |
| Waist and hips circumference | Waist and hips circumference (cm) | 18 days |
| Measurement of neck | Measurement of neck (cm) | 18 days |
| Anthropometric measurements | Measurement of BMI Z-score | 18 days |
| Appetite | appetite evaluation by visual analog scale before each meal | 18 days |
| Hunger | hunger evaluation by visual analog scale before each meal | 18 days |
| Fasting IL6-8 levels | 18 days |
| Fasting adiponectin | 18 days |
| Fasting resistin | 18 days |
| Fasting MCP1 | 18 days |
| Fasting PostPrandial | 18 days |
| Fasting GLP1 (glucagon-like peptide-1) | 18 days |
| Fasting Hba1C | 18 days |
| Body mass index z score | 18 days |
| sleep duration | 18 days |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |