The Effect of Acipimox on GLP (Glucagon-like Peptide)-1 Secretion

The Effect of Acipimox on GLP-1 Secretion in Healthy Subjects: a Pilot Study

Glucagon like peptide 1 is produced in enteroendocrine L cells in the small intestine stimulated by peroral food intake. GLP-1 induces insulin secretion, and analogues are used in the treatment of DM2 (type 2 diabetes mellitus). Recently it was found, that levels of GLP-1 are increased in response to acipimox. The hypothesis is that G protein coupled receptors on enteroendocrine L cells bind acipimox and thereby induce GLP-1 secretion.

In a controlled, open, randomized experiment, eight healthy, overweight men will be studied on an intervention day, where they receive acipimox, and on a control day. The study day includes an OGTT (oral glucose tolerance test), blood samples before and after the OGTT and a biopsy from adipose tissue.

Inclusion Criteria:

• Adult men
• Healthy
• BMI 25-35

Exclusion Criteria:

• Known DM2
• Receiving hypolipidemic drugs