Ocular Penetration of Topical Tacrolimus Eye Drops | NCT02794610 | Trialant

Ocular Penetration of Topical Tacrolimus Eye Drops | NCT02794610 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Topical tacrolimus	Experimental	Ten patients will be include. Topical tacrolimus 0.05% will be instilled into the eyes of patients 15 minutes before cataract surgery. Aqueous samples will be collected at the time of cataract surgery and will be subjected to detection of presence and level of tacrolimus.	Drug: Tacrolimus

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Tacrolimus	Drug	Topical tacrolimus 0.05% eye drops will be instilled into the eyes of patients every minute for 5 minutes. After 15 minutes, at the time of cataract surgery, aqueous samples will be collected and will be subjected to detection of presence and level of tacrolimus.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Detection of the concentration of tacrolimus ( nanograms/milliliter) in the anterior chamber following ocular topical application.		From date of obtaining the aqueous samples until getting the laboratory results of concentration of topical tacrolimus in the aqueous humor up to 2 months

Contacts/Locations Module

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
32025589	Derived	Shoughy SS, Aljassar FM, Tabbara KF. Aqueous penetration of topical tacrolimus. Am J Ophthalmol Case Rep. 2020 Jan 17;17:100582. doi: 10.1016/j.ajoc.2019.100582. eCollection 2020 Mar.

Condition Browse Module