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| Name | Class |
|---|---|
| Physikalisch-Technische Bundesanstalt Institut Berlin (PTB) | OTHER |
The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in older people, compared to sham tDCS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tDCS | Experimental | Anodal stimulation during resting state fMRI |
|
| Cathodal tDCS | Experimental | Cathodal stimulation during resting state fMRI |
|
| sham tDCS | Sham Comparator | Sham stimulation during resting state fMRI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device |
| ||
| sham-tDCS |
| Measure | Description | Time Frame |
|---|---|---|
| GABA concentration assessed by magnetic resonance spectroscopy (MRS) before and after anodal tDCS adjusted for baseline levels | Investigation whether anodal tDCS leads to a significant reduction of M1-GABA concentration in older adults compared to sham stimulation. | assessed immediately before and after a 15-min stimulation time |
| Measure | Description | Time Frame |
|---|---|---|
| GABA concentration assessed by MRS before and after cathodal tDCS adjusted for baseline levels | To assess stimulation effects on GABA concentration by magnetic resonance spectroscopy are measured before and after cathodal tDCS. | assessed immediately before and after a 15-min stimulation time |
| Resting-state functional connectivity changes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, Prof. Dr. | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité Universitätsmedizin Berlin | Berlin | State of Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26381352 | Background | Bachtiar V, Near J, Johansen-Berg H, Stagg CJ. Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation. Elife. 2015 Sep 18;4:e08789. doi: 10.7554/eLife.08789. | |
| 26279408 | Background | Amadi U, Allman C, Johansen-Berg H, Stagg CJ. The Homeostatic Interaction Between Anodal Transcranial Direct Current Stimulation and Motor Learning in Humans is Related to GABAA Activity. Brain Stimul. 2015 Sep-Oct;8(5):898-905. doi: 10.1016/j.brs.2015.04.010. Epub 2015 May 1. |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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|
Functional connectivity as measured by resting-state fMRI during tDCS compared to sham |
| assessed during a 15-min stimulation time |
| Genotyping of learning related polymorphisms | To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed. | assessed during baseline screening |
| 24668166 | Background | Stagg CJ, Bachtiar V, Amadi U, Gudberg CA, Ilie AS, Sampaio-Baptista C, O'Shea J, Woolrich M, Smith SM, Filippini N, Near J, Johansen-Berg H. Local GABA concentration is related to network-level resting functional connectivity. Elife. 2014 Mar 25;3:e01465. doi: 10.7554/eLife.01465. |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |