fMRI of Flight of Ideas in Bipolar Disorder | NCT02794129

Studies
fMRI of Flight of Ideas in Bipolar Disorder

NCT02794129

Sponsor

CHU de Reims

Status

Completed

Last Update Posted

Jan 21, 2026Actual

Enrollment

79Actual

Phase

Not Applicable

Conditions

Bipolar Disorder

Interventions

Functional Magnetic Resonance Imaging

Countries

France

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

May 2016

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Aug 2013Actual

Primary Completion Date

Apr 2018Actual

Completion Date

Sep 2018Actual

First Submitted Date

May 30, 2016

First Submission Date that Met QC Criteria

Jun 7, 2016

First Posted Date

Jun 8, 2016Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jan 19, 2026

Last Update Posted Date

Jan 21, 2026Actual

Description Module

Brief Summary

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal probably result from an underlying disturbance in semantic networks dealing with semantic associations. The aim of our study will be to have a better comprehension of thought disorders in bipolar disorder by cognitive exploration of semantic processing.

Detailed Description

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. During these episodes, formal thought disorders are observed, associated to emotional perturbation, behaviour troubles and some psychotic symptoms. During mania, the type of thought disorders observed are derailment, flight of ideas, with an increase in the amount of spontaneous speech and loss of goal. These observations of the patient's speech and language behaviour probably result from an underlying disturbance in semantic networks dealing with semantic associations. These networks have been studied extensively in schizophrenia but remain unknown in bipolar disorder. In this context, the aim of our study will be to have a better comprehension of formal thought disorders in bipolar disorder by cognitive exploration of semantic activation and inhibition.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

79Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Bipolar Disorder patients	Experimental		Other: Functional Magnetic Resonance Imaging
Healthy Controls	Experimental		Other: Functional Magnetic Resonance Imaging

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Functional Magnetic Resonance Imaging	Other		Bipolar Disorder patients Healthy Controls

Measure	Description	Time Frame
brain activation profiles by Functional Magnetic Resonance Imaging		inclusion visit

Eligibility Module

Eligibility Criteria

Inclusion criteria

BD patients :

Men or women, right-handed
diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria
aged from 18 to 65 years-old
Native French speaker
Affiliated to the social security

Healthy Controls (HC):

Men or women, right-handed
aged from 18 to 65 years-old
Native French speaker
Affiliated to the social security

Exclusion criteria

BD patients :

recent alcohol and/or drug abuse or dependence
significant general medical illness, including neurological disorders or head trauma
sensorial impairment (visual and/or hearing)
Contraindication to the use of MRI

HC:

first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV
recent alcohol and/or drug abuse or dependence
significant general medical illness, including neurological disorders or head trauma
sensorial impairment (visual and/or hearing)
Contraindication to the use of MRI

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

65 Years

Standard Ages

AdultOlder Adult

Study Population

Not provided

Sampling Method

Not provided

Facility	Status	City	State	ZIP	Country	Contacts
Chu Reims		Reims		51092	France

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
29670548	Result	Raucher-Chene D, Terrien S, Gierski F, Obert A, Caillies S, Besche-Richard C, Kaladjian A. Neural Correlates of Semantic Inhibition in Relation to Hypomanic Traits: An fMRI Study. Front Psychiatry. 2018 Apr 4;9:108. doi: 10.3389/fpsyt.2018.00108. eCollection 2018.

ID	Term
D000068105	Bipolar and Related Disorders
D019964	Mood Disorders
D001523	Mental Disorders