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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01DA040513-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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This study addresses the disproportionate representation of men who have sex with men (MSM) in the human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) pandemic in Kazakhstan, a country that has seen some of the largest growth in new HIV infections since the turn of the century. Using a stepped wedge trial across 3 cities in Kazakhstan, the proposed study will test a strategic and innovative social network-based intervention for MSM who use drugs in Kazakhstan as a strategy to increase their numbers in the HIV continuum of care.
The intervention is designed to utilize MSM as experts and leverage social network processes to increase the number of MSM in Kazakhstan to be engaged in the HIV continuum of care. The unit of randomization will be a city, with the timing of roll-out of the social network-based intervention in each of the study's cities-Almaty, Nur-Sultan (formerly Astana), and Shymkent-under experimental control. Receipt/delivery of an intervention to enrolled participants will depend on whether the city is in the intervention delivery phase or not. If a participant is in a city during a time period where the intervention is not being delivered then for that time period, the participant is in the control condition. If the participant is in a city during a time period where the intervention is being delivered then the participant (in fact, all participants in that city) will be considered assigned to the intervention group at that time. In theory, all participants will have the opportunity to experience and receive the intervention. Some participants will be enrolled after the intervention has been rolled out in the city in which they reside; thus, they will only experience the intervention condition and not the control condition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peer Unity | Experimental | Subjects assigned to this arm would receive a 4-session, group-delivered intervention focusing on peer/social network-based recruitment and referral program to receive HIV prevention and treatment services in the community. |
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| Pre-implementation | No Intervention | Subjects assigned to this arm would not receive the group-delivered intervention. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Peer Unity | Behavioral | A 4-session, group-delivered intervention focusing on peer/social network-based recruitment and referral program to receive HIV prevention and treatment services in the community. |
| Measure | Description | Time Frame |
|---|---|---|
| Engagement in the HIV care continuum: HIV testing | Has participant received an HIV test in the past 6 months | Past 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| For PLWH, engagement in the HIV care continuum related to HIV medical treatment | For PLWH, visiting AIDS center, receiving ART, and/or achieving viral suppression (descriptive/exploratory due to limited statistical power given only a smaller fraction of sample will have known HIV infection) | Since confirmed HIV infection diagnosis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elwin Wu, PhD | Columbia University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Columbia University School of Social Work | New York | New York | 10027 | United States | ||
| Global Health Research Center of Central Asia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41733746 | Derived | Wu E, Lee YG, Vinogradov V, Zhakupova G, Mergenova G, Davis A, Paine EA, Hunt T, Reeder K, Primbetova S, Terlikbayeva A, Laughney C, Chang M, Baiserkin B, Abishev A, Tukeyev M, Abdraimov S, Denebayeva A, Kasymbekova S, Tazhibayeva G, Kozhakhmet M. A Stepped-Wedge Cluster Randomized Trial of PRIDE in HIV Care: A Crowdsourcing and Peer-Actuated Network Intervention to Increase Engagement in the HIV Care Continuum for Sexual Minority and Gender Expansive Men in Kazakhstan. AIDS Behav. 2026 Feb 24. doi: 10.1007/s10461-026-05079-5. Online ahead of print. | |
| 39399678 |
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All IPD that underlie results in a publication will be shared: (1) in accordance with journal requirements, and/or (2) via publicly accessible data repository (e.g., Academic Commons)
With or after publication, in perpetuity
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| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D006716 | Homosexuality |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D019529 | Sexuality |
| D012725 | Sexual Behavior |
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Stepped-wedge design
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| Almaty |
| Kazakhstan |
| Derived |
| Reeder KG, Lee YG, Sung J, Vinogradov V, Zhakupova G, Mergenova G, Davis A, Paine EA, Primbetova S, Terlikbayeva A, Kali S, Hunt T, Wu E. Trans Health is Public Health: The Prevalence of HIV Among Trans and Gender Expansive People in Kazakhstan. Res Sq [Preprint]. 2024 Sep 24:rs.3.rs-5124958. doi: 10.21203/rs.3.rs-5124958/v1. |
| 39132483 | Derived | Wu E, Lee YG, Vinogradov V, Zhakupova G, Mergenova G, Davis A, Paine EA, Hunt T, Reeder K, Primbetova S, Terlikbayeva A, Laughney C, Chang M, Baiserkin B, Abishev A, Tukeyev M, Abdraimov S, Denebayeva A, Kasymbekova S, Tazhibayeva G, Kozhakhmet M. Increasing HIV Testing Among Sexual and Gender Expansive Men in Kazakhstan: A Stepped-Wedge Randomized Trial of a Community-Level Intervention. medRxiv [Preprint]. 2024 Aug 2:2024.08.01.24311235. doi: 10.1101/2024.08.01.24311235. |
| D001519 |
| Behavior |