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| Name | Class |
|---|---|
| Ege University School of Medicine, Izmir, Turkey | UNKNOWN |
| Dokuz Eylul University | OTHER |
| Diskapi Yildirim Beyazit Education and Research Hospital | OTHER_GOV |
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Primary aim of the TURKAPNE (The Turkish Sleep Apnea Database) study is to generate a cross-sectional nationwide database to define clinical and polysomnographic characteristics of the sleep apnea patients in Turkey. Associations of phenotypes of sleep apnea patients with metabolic and cardiovascular diseases as well as risk for traffic accidents will be explored as secondary aims. Impact of treatment of sleep apnea on metabolic and cardiovascular complications as well as compliance with positive airway pressure treatment will be further explored longitudinally.
All subjects undergoing sleep study for suspicion of obstructive sleep apnea will be registered in a web-based national database regarding:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obstructive Sleep Apnea (OSA) | Patients with apnea hypopnea index of at least 5 events per hour. Intervention with positive airway pressure, or intraoral device, or uvuloplasty, or conservative treatment. |
| |
| No-OSA | Patients with apnea hypopnea index less than 5 events per hour. No intervention. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Positive Airway Pressure (PAP) | Device | Treatment of OSA with PAP |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic and cardiovascular diseases in obstructive sleep apnea phenotypes | The association of sleep apnea severity indices such as Apnea-Hypopnea Index and Oxygen Desaturation Index during Rapid Eye Movement (REM) sleep and non-REM sleep with self-reported diabetes mellitus and cardiovascular diseases will be explored. | Up to three years |
| Measure | Description | Time Frame |
|---|---|---|
| Sex differences in obstructive sleep apnea phenotypes | Possible sex differences in REM-dependent sleep apnea, positional sleep apnea and its association with metabolic and cardiovascular diseases will be explored | Up to three years |
| Adherence to positive airway pressure treatment in obstructive sleep apnea |
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Inclusion Criteria:
Exclusion Criteria:
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All consecutive patients referred to the sleep clinics for suspicion of sleep apnea
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yüksel Peker, Prof | Contact | +905443483866 | yukselpeker26@gmail.com | |
| Baran Balcan, Assoc. Prof | Contact | +905304142308 | drbaranbalcan@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Yüksel Peker, Prof | Koç University School of Medicine, Dept of Pulmonary Medicine | Study Chair |
| Özen Kacmaz Basoglu, Prof | Ege University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Koç University Hospital | Recruiting | Istanbul | TR 34010 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30083405 | Background | Peker Y, Basoglu OK, Firat H; TURKAPNE Study Group. Rationale and Design of the Turkish Sleep Apnea Database - TURKAPNE: A National, Multicenter, Observational, Prospective Cohort Study. Turk Thorac J. 2018 Jul;19(3):136-140. doi: 10.5152/TurkThoracJ.2018.18097. Epub 2018 Jul 1. | |
| 42390661 | Derived | Gurkan CG, Pihtili A, Kiyan E, Tasbakan MS, Basoglu OK, Arbatli S, Aydin S, Cilli A, Dursunoglu N, Baran B, Peker Y; Turkapne Study Group. Diabetes mellitus is associated with increased prevalence and severity of COMISA: evidence from the nationwide TURKAPNE cohort. J Clin Sleep Med. 2026 Jul 2;22(1):103. doi: 10.1007/s44470-026-00109-4. |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D000072700 | Conservative Treatment |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Uludag University |
| OTHER |
| Dicle University School of Medicine, Diyarbakir, Turkey | UNKNOWN |
| Namik Kemal University School of Medicine, Tekirdag | OTHER |
| Suleyman Demirel University School of Medicine, Isparta, Turkey | UNKNOWN |
| Istanbul University - Cerrahpasa | OTHER |
| Pamukkale University School of Medicine, Denizli, Turkey | UNKNOWN |
| Trakya University | OTHER |
| Afyon Kocatepe University School of Medicine, Afyon, Turkey | UNKNOWN |
| Hitit University School of Medicine, Corum, Turkey | UNKNOWN |
| Istanbul Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital | OTHER |
| Kocaeli Education and Research Hospital, Kocaeli, Turkey | UNKNOWN |
| Baskent University Ankara Hospital | OTHER |
| Marmara University | OTHER |
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| Intraoral device (IOD) |
| Device |
Treatment of OSA with IOD |
|
| Uvuloplasty | Procedure | Uvuloplasty |
|
| Conservative treatment | Other | No active intervention |
|
Predictors of adherence to positive airway pressure treatment (defined as device usage at least 4 hours of night during at least 70% of study period) in obstructive sleep apnea |
| Through study completion, an average of 7 years |
| Incidence of cardiovascular diseases and mortality | Number of patients who have died or developed cardiovascular diseases | Through study completion, an average of 7 years |
| Hikmet Firat, Assoc. Prof |
| Ankara Diskapi Yildirim Beyazit Education and Research Hospital |
| Principal Investigator |
| Oya Itil, Prof | Dokuz Eylul University Medical School | Principal Investigator |
| Mehmet Karadag, Prof | Uludag University Medical School | Principal Investigator |
| Nejat Altintas, Assoc. Prof | Namik Kemal University Medical School | Principal Investigator |
| Gökhan Kirbas, Prof | Dicle University Medical School | Principal Investigator |
| Önder Öztürk, Assoc. Prof | Süleyman Demirel University Medical School | Principal Investigator |
| Derya Karadeniz, Prof | Istanbul University Cerrahpasa Medical School | Principal Investigator |
| Nese Dursunoglu, Assoc. Prof | Pamukkale University Medical School | Principal Investigator |
| Gundeniz Altiay, Prof | Trakya University Medical School | Principal Investigator |
| Ersin Günay, Assoc. Prof | Afyon Kocatepe University Medical School | Principal Investigator |
| Sema Sarac, MD | Istanbul Sureyyapasa Education and Research Hospital | Principal Investigator |
| Zahide Yilmaz, MD | Kocaeli Education and Research Hospital | Principal Investigator |
| Aylin Ozsancak Ugurlu, Assoc. Prof | Istanbul Baskent University Hospital | Principal Investigator |
| Kadriye Agan Yildirim, Prof | Marmara University, Faculty of Medicine, Department of Neurology | Principal Investigator |
| Sertac Arslan, Assist Prof | Corum Hitit University | Principal Investigator |
| 39721358 | Derived | Pihtili A, Kiyan E, Balcan B, Arbatli S, Cilli A, Altintas N, Ugurlu AO, Gurkan CG, Tasbakan MS, Dursunoglu N, Ogun H, Annakkaya AN, Sokucu SN, Firat H, Basoglu OK, Peker Y; Turkapne Study Group. Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort. Sleep Med. 2025 Feb;126:228-234. doi: 10.1016/j.sleep.2024.12.018. Epub 2024 Dec 17. |
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |