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The purpose of this study is to evaluate the application of Negative AV Hysteresis (NAVH) to improve electrical synchrony in MultiPoint Pacing (MPP) Cardiac Resynchronization Therapy (CRT) patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRT+NAVH | Surface ECG and pressure-volume loop recordings will be taken during the adjustment of programmable Cardiac Resynchronization Therapy and Negative Atrioventricular Hysteresis settings at the device implant procedure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CRT+NAVH | Device | Cardiac Resynchronization Therapy with Negative Atrioventricular Hysteresis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acute change in QRS duration due to CRT with NAVH, relative to intrinsic conduction | Acute changes in surface ECG QRS duration resulting from Cardiac Resynchronization Therapy (CRT) with Negative Atrioventricular Hysteresis (NAVH) over a range of programmable values | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Acute changes in LV pressure-volume hemodynamics due to CRT with NAVH, relative to intrinsic conduction | Acute changes in left ventricular pressure-volume hemodynamics resulting from Cardiac Resynchronization Therapy with Negative Atrioventricular Hysteresis over a range of programmable values | 1 day |
| Change in QRS duration after one day of CRT with NAVH, relative to intrinsic conduction |
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Inclusion Criteria:
Exclusion Criteria:
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Enrollment will include patients scheduled to be implanted with MultiPoint Pacing-enabled SJM Quadripolar Pacing Systems
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| I.R.C.C.S. Policlinico San Donato | San Donato Milanese | MI | 20097 | Italy |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Changes in surface ECG QRS duration after one day of Cardiac Resynchronization Therapy with Negative Atrioventricular Hysteresis |
| 1 day |