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| ID | Type | Description | Link |
|---|---|---|---|
| 7/10/15 | Other Identifier | Local Ethics Commission | |
| 01681 | Other Identifier | UMG study center |
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Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion.
Total protein concentration within the formed salivary pellicles on the bovine samples is determined. Further Salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, albumin and total protein content as well as concentration of inorganic calcium, phosphate and fluoride) are being measured.
The aim of this study is to investigate whether gender differences in the salivary composition correlate with predisposition to erosion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Females | Female volunteers |
| |
| Males | Male volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wearing of an intraoral device with bovine tooth samples | Other | Wearing of an intraoral device with bovine tooth samples |
|
| Measure | Description | Time Frame |
|---|---|---|
| Calcium release from bovine enamel and dentin samples by extraoral erosion (nmol/Square Millimeter). | Immediately after the intraoral device has been worn once for two hours. |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of unstimulated and stimulated saliva flow rate (mL/min). | Saliva samples are collected for 5 min each on two visits. | |
| Determination of saliva pH. | Saliva samples are collected for 5 min each on two visits. |
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Inclusion Criteria:
Exclusion Criteria:
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Exploratory study
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| Name | Affiliation | Role |
|---|---|---|
| Annette Wiegand, Prof. Dr. med. dent. | Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Center Göttingen, Dept. of Preventive Dentistry, Periodontology and Cariology | Göttingen | Lower Saxony | 37075 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25809904 | Background | Prodan A, Brand HS, Ligtenberg AJ, Imangaliyev S, Tsivtsivadze E, van der Weijden F, Crielaard W, Keijser BJ, Veerman EC. Interindividual variation, correlations, and sex-related differences in the salivary biochemistry of young healthy adults. Eur J Oral Sci. 2015 Jun;123(3):149-57. doi: 10.1111/eos.12182. Epub 2015 Mar 23. | |
| 24603346 |
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| ID | Term |
|---|---|
| D014077 | Tooth Erosion |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D057085 | Tooth Wear |
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Saliva samples are obtained and retained for 10 years.
| Determination of salivary buffer capacity. | Saliva samples are collected for 5 min each on two visits. |
| Determination of albumin (mg/L) in saliva. | Saliva samples are collected for 5 min each on two visits. |
| Determination of total protein content (mg/L) in saliva. | Saliva samples are collected for 5 min each on two visits. |
| Determination of inorganic calcium (mmol/l), phosphate (mmol/L) and fluoride (µmol/L) in saliva. | Saliva samples are collected for 5 min each on two visits. |
| Determination of total protein concentration in the formed salivary pellicles (ng/Square Millimeter). | Immediately after the intraoral device has been worn once for two hours. |
| Carpenter G, Cotroneo E, Moazzez R, Rojas-Serrano M, Donaldson N, Austin R, Zaidel L, Bartlett D, Proctor G. Composition of enamel pellicle from dental erosion patients. Caries Res. 2014;48(5):361-7. doi: 10.1159/000356973. Epub 2014 Mar 6. |
| 24993266 | Background | Moazzez R, Bartlett D. Intrinsic causes of erosion. Monogr Oral Sci. 2014;25:180-96. doi: 10.1159/000360369. Epub 2014 Jun 26. |
| 18607835 | Background | Wiegand A, Bliggenstorfer S, Magalhaes AC, Sener B, Attin T. Impact of the in situ formed salivary pellicle on enamel and dentine erosion induced by different acids. Acta Odontol Scand. 2008 Aug;66(4):225-30. doi: 10.1080/00016350802183401. |
| 18523383 | Background | Wiegand A, Meier W, Sutter E, Magalhaes AC, Becker K, Roos M, Attin T. Protective effect of different tetrafluorides on erosion of pellicle-free and pellicle-covered enamel and dentine. Caries Res. 2008;42(4):247-54. doi: 10.1159/000135669. Epub 2008 Jun 4. |
| 23774653 | Background | Zwier N, Huysmans MC, Jager DH, Ruben J, Bronkhorst EM, Truin GJ. Saliva parameters and erosive wear in adolescents. Caries Res. 2013;47(6):548-52. doi: 10.1159/000350361. Epub 2013 Jun 15. |
| 27022647 | Background | Kanzow P, Wegehaupt FJ, Attin T, Wiegand A. Etiology and pathogenesis of dental erosion. Quintessence Int. 2016 Apr;47(4):275-8. doi: 10.3290/j.qi.a35625. |
| 31163440 | Result | Wiegand A, Rosemann A, Hoch M, Barke S, Dakna M, Kanzow P. Erosion-Protective Capacity of the Salivary Pellicle of Female and Male Subjects Is Not Different. Caries Res. 2019;53(6):636-642. doi: 10.1159/000500046. Epub 2019 Jun 4. |