Reproductive Outcome of EM Treated by GnRH-a Associated With Laparoscopy

Efficacy of Laparoscopic Surgery Combined With GnRH-a in the Treatment of Endometriosis Associated Infertility: A Multicenter, Prospective, Randomized-control-trial

This study is a multicenter, randomized-control-trial. This study select 1184 Infertile patients associated with endometriosis diagnosed by laparoscopy surgery. Patients are going to be divided into two groups according to 1:1 ratio randomly assigned to receive GnRH-a. Cumulative pregnancy rate, end of treatment to natural pregnancy time, accept the assisted reproductive treatment rate, miscarriage rate, live birth rate will be recorded.

Inclusion Criteria:

• Infertile patients
• Endometriosis I-II phase：according to Revised American Society for Reproductive Medicine classification of endometriosis: 1996
• BMI:19-28 kg/㎡
• Ovarian reserve function is normal（M2-5：bilateral antral follicles≥6 FSH：5-12U/ml）

Exclusion Criteria:

• Male factor causes infertility
• hydrosalpinx or salpingemphraxis
• Uterine malformation
• Uterine cavity lesion
• Contra-indications for GnRH-a
• not willing to participate