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This study aims to determine the effect of acute hypnotic intake (Zolpidem) on sleep, cognitive and motor performances and on acute mountain sickness symptoms at high altitude. Healthy subjects will be evaluated on 4 occasions (twice at sea level and twice at high altitude), after hypnotic or placebo intake. Following an early wake-up (01:00), symptoms, cognitive and motor performances will be assessed to determine potential residual effects of Zolpidem within such conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zolpidem Normoxia | Experimental | Acute zolpidem intake at sea level |
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| Placebo Normoxia | Sham Comparator | Acute placebo intake at sea level |
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| Zolpidem Hypoxia | Experimental | Acute zolpidem intake at high altitude |
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| Placebo Hypoxia | Sham Comparator | Acute placebo intake at high altitude |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Zolpidem | Drug | The hypnotic will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive performance assessed using Simon cognitive test | Simon cognitive test | 4 hours after drug/placebo intake |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre Bouzat, MD PhD | University Hospital, Grenoble | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Grenoble University Hospital | Grenoble | Auvergne-Rhône-Alpes | 38043 | France |
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| ID | Term |
|---|---|
| D000077334 | Zolpidem |
| ID | Term |
|---|---|
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Placebo | Drug | The placebo will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment. |
|