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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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Cancer patients with chemotherapy-induced peripheral neuropathy (CIPN) have deficits in sensory and motor skills leading to inappropriate proprioceptive feedback, impaired postural control and high fall risk. This study will investigate the acceptability and effect of an interactive motor adaptation balance training program based on wearable sensors for improving balance in older cancer patients with CIPN. Cancer patients with confirmed CIPN will be recruited and will be randomized to either intervention (IG) or control (CG) group and followed for 6 months. The intervention group will take part in a 6-week balance training program twice per week in either their home or in clinic (based on subject preference) under the supervision of a qualified research staff member. This intervention includes interactive game-based balance training including repetitive weight shifting and virtual obstacle crossing tasks. Wearable sensors will provide real-time visual/auditory feedback from foot and ankle position and allowed perception of motor-errors during each motor-action. The control group will be instructed to complete a supervised foot and ankle exercise without using sensor technology. Changes in balance, gait, and physical activity, and number of falls will be compared pre- and post-intervention, as well as 3 and 6 month post intervention. Investigators hypothesize that patients receiving sensor-based exercise training will benefit more compared to group receiving conventional non-technology home-based training in terms of improving functional performance and reducing falls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention with game-based exercise | Experimental | Subjects will be receiving sensor-based interactive exercise program (game-based exercise) intervention twice a week for 6 weeks. |
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| Intervention without game-based exercise | Active Comparator | Subjects will be receiving non-technology based foot and ankle exercise twice a week for 6 weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sensor-based interactive exercise (game-based exercise) | Other | This intervention includes interactive game-based balance training including repetitive weight shifting and virtual obstacle crossing tasks. Wearable sensors will provide real-time visual/auditory feedback from foot and ankle position and allowed perception of motor-errors during each motor-action. |
| Measure | Description | Time Frame |
|---|---|---|
| Gait Speed change from Baseline to 6 weeks, three months and six months | walking ability is quantified by gait speed. | Baseline, 6 weeks, three months, six months |
| Balance change from Baseline to 6 weeks, three months and six months | balance is quantified by body sway | Baseline, 6 weeks, three months, six months |
| Measure | Description | Time Frame |
|---|---|---|
| Fear of falling change from Baseline to 6 weeks | Measuring fear of falling using Fall Efficacy Scale International (FES-I) questionnaire | Baseline and 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baylor College of Medicine | Houston | Texas | 77030 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26678611 | Result | Schwenk M, Grewal GS, Holloway D, Muchna A, Garland L, Najafi B. Interactive Sensor-Based Balance Training in Older Cancer Patients with Chemotherapy-Induced Peripheral Neuropathy: A Randomized Controlled Trial. Gerontology. 2016;62(5):553-63. doi: 10.1159/000442253. Epub 2015 Dec 18. | |
| 30665876 | Result | Zahiri M, Chen KM, Zhou H, Nguyen H, Workeneh BT, Yellapragada SV, Sada YH, Schwenk M, Najafi B. Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults - Toward an early diagnosis of CIPN. J Geriatr Oncol. 2019 Nov;10(6):960-967. doi: 10.1016/j.jgo.2019.01.010. Epub 2019 Jan 18. |
| Label | URL |
|---|---|
| obstacle crossing exergame | View source |
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Only de-identified data and associated results will be published in peer-review papers or scientific abstracts.
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D000088544 | Exergaming |
| D008722 | Methods |
| ID | Term |
|---|---|
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
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| Intervention without game-based exercise | Other | Subjects are asked to perform non-technology based foot and ankle exercises, which include body weight shifting and obstacle crossing tasks. |
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| D055687 |
| Musculoskeletal and Neural Physiological Phenomena |
| D008919 | Investigative Techniques |