The purpose of this study is to find out the capacity of standardized uptake value (SUV) using single-photo emission computed tomography and computed tomography (SPECT/CT) in diagnosing Grave's Disease (hyperthyroidism).

Traditionally it is considered that only positron emission tomography(PET) has the ability to obtain standardized uptake value（SUV）while single-photo emission computed tomography(SPECT) does not have. Recently with the developing of technology, the ability of SPECT has been extended.

On the other hand, thyroid imaging by SPECT can only play an auxiliary role in hyperthyroidism diagnosis mainly since it is regarded as nonquantitative. So the investigators design this study to search the capacity and accuracy of SUV provided by SPECT and CT(CT is used for reconstruction algorithm) in diagnosing GD.

This is a multiple-center study containing nine groups in China that use GE Discovery NM/CT, an advanced equipment. Thus, the data can be more accurate and more available.

And this is a perspective clinical trial, taking about eight months. The investigators plan to evaluate at least 50 Grave's Disease(GD) patients and 50 normal humans as contrast in all.

Every GD patient must have been diagnosed and the results of thyroid function tests(such as TSH,FT3,FT4） must be available. If necessary, the patient's rate of iodine uptake should also be known before he/she being included in this study. As for normal people, the results of thyroid function tests should be within the range of normal value.

The data of each participant will be gathered and stored. And the data processing will be done with the help of GE staff, using the software Q.Metrix to get the value of SUVmean, SUVmax. Finally T test will be used in comparison of the differences.

For Group of GD Patients:

Inclusion Criteria:

• certainly diagnosed with GD
• no treatment
• sign a informed consent

Exclusion Criteria:

• Inflammatory Hyperthyroidism
• Secondary Hyperthyroidism (since of medicine, thyrotrophs neoplasms and etc)
• Can not finish the check of SPECT/CT
• Refuse to sign a informed consent

For Group of Normal Humans:

Inclusion Criteria:

• without GD
• Adult
• sign a reformed consent

Exclusion Criteria:

• Without normal values of TSH, FT3, FT4
• Can not finish the check of SPECT/CT
• Failed to sign a reformed consent

As for GD patients, the study samples will be chosen from the patients in every medical center which participates in this study. And they will be chosen before their treatment.

For the normal humans, they are healthy volunteers without thyroid disease.

The data of the subjects will be shared including gender, age, values of SUV, TSH, FT3, FT4 and other relative records.

The information will not be shared until the study is completed and the article is published.

Anyone who wants to get the data should send an e-mail to Li, with reasons for needing these data.

E-mail address: 617381606@qq.com