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| Name | Class |
|---|---|
| National Institute for Health Research, United Kingdom | OTHER_GOV |
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The aim of this project is to estimate the quality of life for people with asthma and specifically the loss in quality of life associated with an asthma-related crisis event (accident and emergency (A&E) attendance or admission).
Asthma is a serious respiratory condition which causes shortness of breath, chest tightness and wheezing. Quality of life can have an impact on asthmatics due to such symptoms. Previous studies capture quality of life at specific time points (e.g. baseline, 1 month, 3 months), and the assumption of a steady improvement is made. However, these assumptions and time points could miss an asthma event in between. Therefore, the investigators aim to provide a more accurate estimation of the loss in quality of life by following participants over an 8 week period from when the participants have attended A&E or been admitted to hospital following an asthma attack. This will be done by using different quality of life methods, and analysed by calculating the difference between the quality of life scores from A&E attendance / hospital admission and follow-ups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asthma | All participants will have an asthma-related crisis event due to an asthma exacerbation that resulted in A&E attendance and/or hospital admission. |
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| Measure | Description | Time Frame |
|---|---|---|
| EuroQol 5 Dimensions 5 Level (EQ-5D-5L) | A generic quality of life questionnaire | Once a week from baseline until week 8 |
| Asthma Quality of Life Questionnaire (AQLQ) | A disease-specific quality of life questionnaire | Once a month from baseline to week 8 |
| Peak flow and asthma symptom diary | Assessment of peak expiratory flow and asthma symptoms | Every day from baseline to week 8 |
| Time Trade-Off | Assessment of quality of life. Completed at Norfolk and Norwich University Hospital only. | Once a month from baseline to week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Productivity Questionnaire | Assessment of time lost from work, study or activities from having an asthma exacerbation | Week 4 |
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Inclusion Criteria:
Exclusion Criteria:
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Asthma patients who have an asthma-related crisis event (attended A&E or have been admitted to hospital).
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| Name | Affiliation | Role |
|---|---|---|
| Christina-Jane Crossman-Barnes, BSc, MSc | University of East Anglia | Principal Investigator |
| Andrew Wilson, MD FRCP | University of East Anglia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Norfolk and Norwich University Hospital | Norwich | Select A County | NR4 7TJ | United Kingdom | ||
| Aberdeen Royal Infirmary |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30971261 | Derived | Crossman-Barnes CJ, Sach T, Wilson A, Barton G. Estimating loss in quality of life associated with asthma-related crisis events (ESQUARE): a cohort, observational study. Health Qual Life Outcomes. 2019 Apr 11;17(1):58. doi: 10.1186/s12955-019-1138-5. |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| Aberdeen |
| AB25 2ZN |
| United Kingdom |
| Queen Elizabeth Hospital Birmingham | Birmingham | B15 2GW | United Kingdom |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |