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| Name | Class |
|---|---|
| Altona Children's Hospital | OTHER |
| Boston Children's Hospital | OTHER |
| Children's Hospital Medical Center, Cincinnati | OTHER |
| Children's Health Andrews Institute for Orthopaedics & Sports Medicine |
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The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.
Patients will be recruited and consented at the visit in which their eligibility is determined. Once a patient is eligible and provides informed consent, he or she will be in the study for up to 50 years, or until his or her OCD lesion is healed successfully.
At the initial visit, a subject will complete a basic medical history form, and three questionnaires: the IKDC Subjective questionnaire (ages over 18) or the PEDI-IKDC Subjective questionnaire (ages under 18); the KOOS questionnaire; and the Marx Activity Scale (adult) or Pedi-FABS Scale (pediatric). Patients will then continue with their normal course of care as determined by their surgeon and care team.
Mandatory surveys (same as above) will be collected from patients at 2 years, 5 years, 10 years, and 25 years. Patients who cannot return to clinic will have the option to complete the assessments and return in pre-stamped and addressed return envelopes provided by the clinical site the subject is a patient at. Any other follow-up visits between these time intervals will also be options for patients to complete these assessments, however patients will not complete them any closer than intervals 12 weeks apart in order to prevent redundancy.
Additionally, at the initial visit, the surgeon will complete a routine patient history and physical exam, which will be collected. Any surgical procedures or physical therapy a patient undergoes for treatment of his or her OCD lesion will also be documented and collected. At follow-up visits, surgeons will complete their own physical exam follow-up assessment forms, which will be collected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with OCD | Patients with diagnosis of OCD as confirmed by x-ray or MRI. Surveys collected from patients at 2 years, 5 years, 10 years, and 25 years. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Other: observational only- no intervention | Other | Other: observational only- no intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| IKDC questionnaire | The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age. | baseline up to 50 years |
| PEDI-IKDC questionnaire | The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age. | baseline up to 50 years |
| Measure | Description | Time Frame |
|---|---|---|
| KOOS Knee score | The Knee injury and Osteoarthritis Outcome Score (KOOS) evaluates short-term and long-term symptoms and function in subjects with knee injury and osteoarthritis. | baseline up to 50 years |
| Marx Activity Score questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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Patients of all ages with osteochondritis dissecans (OCD) or focal articular cartilage defects confirmed via MRI or x-ray.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mounika Ponakala, MS | Contact | 6093343767 | mounika.ponakala@pennmedicine.upenn.edu |
| Name | Affiliation | Role |
|---|---|---|
| James L Carey, MD | University of Pennsylvania | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pennsylvania | Recruiting | Philadelphia | Pennsylvania | 19104 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41981903 | Derived | ROCK Group; Nissen CW, Albright JC, Anderson CN, Busch MT, Carey JL, Carlson C, Carsen S, Chambers HG, Crepeau A, Edmonds EW, Ellermann JM, Ellis HB Jr, Erickson JB, Fabricant PD, Godin J, Ganley TJ, Green DW, Grimm NL, Heyworth BE, Hui Hoi Po J, Kocher MS, Koehler R, Krych AJ, Latz KH, Loveland DM, Lyon RM, Meenen NM, Milewski MD, Myer GD, Nelson BJ, Nepple JJ, Nguyen JC, Pace JL, Paterno MV, Pennock AT, Perkins CA, Polousky JD, Riley P, Saluan P, Shea KG, Tompkins MA, Wall EJ, Weiss JM, Willimon SC, Wilson PL, Wright RW, Kostyun RO. The Efficacy of Bracing in Nonoperative Care of Medial Femoral Condyle Osteochondritis Dissecans: A Study From the Research in Osteochondritis Dissecans of the Knee (ROCK) Study Group. Am J Sports Med. 2026 May;54(6):1415-1422. doi: 10.1177/03635465261429407. Epub 2026 Apr 14. |
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| ID | Term |
|---|---|
| D010008 | Osteochondritis Dissecans |
| ID | Term |
|---|---|
| D010007 | Osteochondritis |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| UNKNOWN |
| Children's Healthcare of Atlanta | OTHER |
| Children's Hospital Colorado | OTHER |
| Children's Hospital of Philadelphia | OTHER |
| Children's Hospital and Health System Foundation, Wisconsin | OTHER |
| Children's Mercy Hospital Kansas City | OTHER |
| Connecticut Children's Medical Center | OTHER |
| Hospital for Special Surgery, New York | OTHER |
| Kaiser Permanente | OTHER |
| Mayo Clinic | OTHER |
| National University Hospital, Singapore | OTHER |
| Rady Children's Hospital, San Diego | OTHER |
| Stanford University | OTHER |
| Tennessee Orthopedic Alliance | OTHER |
| Texas Scottish Rite Hospital for Children | OTHER |
| The Rocky Mountain Hospital for Children | UNKNOWN |
| The Hospital for Sick Children | OTHER |
| Göteborg University | OTHER |
| University of Minnesota/TRIA Orthopaedic Center | UNKNOWN |
| Washington University School of Medicine | OTHER |
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Measure of physical activity at healthiest and most active state from time of taking to year prior.
| baseline up to 50 years |
| Pedi-FABS Score | An eight-item scale that measures level of physical activity and fitness. | baseline up to 50 years |
| Radiographic Healing | Visualization of bone healing through x-ray images. | baseline up to 50 years |