Impact of Interferon Free Regimens in Patients With Chronic HCV and Successfully Treated HCC

Impact of Interferon Free Regimens in Patients With Chronic HCV and Successfully Treated HCC

The study will recruit 150 patients with HCV related HCC ,after HCC treatment the patients will undergo treatment with different regimens of DAAs.

The study will recruit 150 patients with HCV related HCC All the studied patients underwent or will undergo one of the curative interventions for HCC either hepatic resection or thermal ablation .

after 1 month of achievement of laboratory and radiological response to HCC intervention the patient will be treated with one of the interferon free regimens :

1. Sofosbuvir+Ribavirin
2. Sofosbuvir+Simeprevir± Ribavirin
3. Sofosbuvir+ Daclatasvir ± Ribavirin
4. Sofosbuvir+ Ledipasvir ± Ribavirin

the treatment duration will be justified either 12 or 24 weeks after treatment the patient will continue on regular follow up to detect HCV cure or recurrence , HCC cure or recurrence and long term follow up of natural history

Inclusion Criteria:

• Age 18-70 years old
• Confirmed HCV viremia by PCR
• CHILD Pugh "A" or "B7,B8"
• Confirmed HCC either by laboratory ,imaging or histopathological criteria
• Underwent or candidate for curative intervention for HCC (BCLC stage 0 ,A)
• Willing to be treated for HCV and signing informed consent

Exclusion Criteria:

• Patients below 18 or above 70 years old
• patients with advanced liver condition "CHILD score ≥ B9"
• Patients with advanced HCC status (BCLC≥ B)
• Patients with combined HBV ,HIV infection