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Evaluate the efficacy, Safety and Pharmacokinetics of Intravenous single injection LC28-0126 immediately before Percutaneous Coronary Intervention (PCI) in Patients with ST-segment Elevation Myocardial Infarction (STEMI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LC28-0126 Dose A | Experimental |
| |
| LC28-0126 Dose B | Experimental |
| |
| LC28-0126 Dose C | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Drug | Placebo |
| |
| LC28-0126 Dose A |
| Measure | Description | Time Frame |
|---|---|---|
| AUC of Troponin I for 72 hours post PCI | pre PCI, PCI 0h, 6h, 12h, 18h, 24h, 48h, 72h |
| Measure | Description | Time Frame |
|---|---|---|
| AUC of CK-MB for 72 hours post PCI | pre PCI, PCI 0h, 6h, 12h, 18h, 24h, 48h, 72h | |
| AUC of CK for 72 hours post PCI | pre PCI, PCI 0h, 6h, 12h, 18h, 24h, 48h, 72h | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | South Korea |
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| Drug |
LC28-0126 Dose A |
|
| LC28-0126 Dose B | Drug | LC28-0126 Dose B |
|
| LC28-0126 Dose C | Drug | LC28-0126 Dose C |
|
| Infarct size assessed by Cardiac MRI |
| Day 4, 30 |
| Myocardial function assessed by Cardiac MRI | Day 4, 30 |
| Myocardial function assessed by Echocardiogram | Day 4, 30 |
| ID | Term |
|---|---|
| D000072657 | ST Elevation Myocardial Infarction |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
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