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| Name | Class |
|---|---|
| Tilburg University | OTHER |
| Reinier de Graaf Groep | OTHER |
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The study assesses cognitive complaints in newly diagnosed patients with obstructive sleep apnea with no medical-comorbity affecting cognition. Cognitive complaints will be compared to healthy controls matched on age, sex and educational level. Factors related to cognitive complaints will also be assessed, including anxiety and depressive symptoms, complaints of fatigue and sleepiness, quality of life, psychological coping strategies and objective measures of cognition. Patients starting treatment for sleep apnea (continuous positive airway pressure or mandibular repositioning device) will be reassessed on all measures after 6 months of treatment to study the impact of treatment as usual on cognitive complaints and its related factors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OSA | Patients with newly diagnosed obstructive sleep apnea and no medical comorbidity affecting cognition. |
| |
| healthy controls | Participants with no sleep disorder or other medical comorbidity affecting cognition. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| questionnaires and neuropsychological assessments | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive Failure Questionnaire (CFQ) | Questionnaire assessing cognitive complaints | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Behavior Rating Inventory of Executive Function Adult version (BRIEF-A) | Questionnaire assessing cognitive complaints | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| Hospital Anxiety and Depression Scale (HADS) | questionnaire assessing anxiety and depressive symptoms | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Fatigue Assessment Scale (FAS) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients newly diagnosed with obstructive sleep apnea according to the clinical guidelines of the adult OSA taskforce of the American Academy of Sleep Medicine (apnea/hypopnea-index (AHI) of ≥15 or AHI of ≥5 with significant daytime symptoms)
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| Name | Affiliation | Role |
|---|---|---|
| Margriet Sitskoorn, PhD | Tilburg University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VieCuri Medisch Centrum | Venlo | Limburg | 5912 BL | Netherlands | ||
| Reinier de Graaf Gasthuis |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40706402 | Derived | Vaessen TJA, Mark RE, Overeem S, Sitskoorn MM. Cognitive complaints in obstructive sleep Apnea: The overlooked role of coping styles. Sleep Med. 2025 Oct;134:106695. doi: 10.1016/j.sleep.2025.106695. Epub 2025 Jul 17. |
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| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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questionnaire assessing fatigue
| Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Epworth Sleepiness Scale (ESS) | questionnaire assessing sleepiness | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Pittsburgh Sleep Quality Index (PSQI) | questionnaire screening for sleep disorders and assessing sleep quality | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Sleep diary | subjective measure for sleep quality | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| World Health Organisation Quality of Life Questionnaire BREF (WHOQOL-bref) | questionnaire measuring quality of life | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Utrechtse Coping Lijst (UCL) | questionnaire measuring psychological coping strategies | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Dutch reading tests for adults (NLV) | cognitive test for verbal intelligence | Assessed at inclusion of study. |
| Central Nervous System Vital Signs Symbol Digit Coding (CNS-VS-SDC) | cognitive test for attention | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Central Nervous System Vital Signs Continuous Performance Test (CNS-VS-CPT) | cognitive test for attention | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Central Nervous System Vital Signs Stroop Test (CNS-VS-ST) | cognitive test for attention/executive function | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Central Nervous System Vital Signs Shifting Attention Test (CNS-VS-SAT) | cognitive test for attention/executive function | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Rey Auditory Verbal Learning Test (RAVLT) | cognitive test for memory | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Wechsler Adult Intelligence Scale III - Digit Span (WAIS-III-DS) | cognitive test for attention/executive function | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Trail Making Test (TMT) | cognitive test for attention/executive function | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Semantic Fluency | cognitive test for executive function | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. |
| Delft |
| South Holland |
| 2625 AD |
| Netherlands |
| D012140 |
| Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |