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Decision-making for treatment of metastatic breast cancer after the second line of chemotherapy was limited by the lack of established predictive factors of benefit for further chemotherapy regimens. Eribulin has emerged as the only single agent demonstrating an overall survival improvement in the third-line setting or beyond. The purpose of this study was to define the clinical profile of metastatic breast cancer participants achieving long-term benefit from chemotherapy with eribulin in the third-line setting or beyond.
This was a multicenter, retrospective, observational, case study analysis to assess long-term eribulin treatment in metastatic breast cancer. The study was conducted in 26 Spanish hospitals participating in a national pre-market access program to eribulin between 2011 and 2014. An exploratory comparison with a group of short-term responders included in a similar observational study was performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants treated with eribulin for at least 7 months |
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| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | up to 7 months | |
| Progression free survival (PFS) | up to 7 months | |
| Objective response rate | up to 7 months | |
| Time to response | up to 7 months | |
| Post progression survival | up to 7 months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with adverse events/serious adverse events/toxic deaths as a measure of safety | up to 7 months |
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Inclusion criteria:
Exclusion criteria:
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Participants with Advanced or Metastatic Breast Cancer on Eribulin for at least 7 months
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Santiago de Compostela | A Coruña | Spain | ||||
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| Las Palmas de Gran Canarias |
| Gran Canaria |
| Spain |
| San Sebastián | Guipuzcoa | Spain |
| Barbastro | Huesca | Spain |
| Alcorcón | Madrid | Spain |
| Aravaca | Madrid | Spain |
| Pozuelo de Alarcón | Madrid | Spain |
| Pamplona | Navarre | Spain |
| Bilbao | Vizcaya | Spain |
| Badajoz | Spain |
| Cáceres | Spain |
| Jaén | Spain |
| Lleida | Spain |
| Madrid | Spain |
| Málaga | Spain |
| Murcia | Spain |
| Ourense | Spain |
| Salamanca | Spain |
| Seville | Spain |
| Valencia | Spain |
| Zaragoza | Spain |
| D017437 |
| Skin and Connective Tissue Diseases |