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The aim of the study is to compare two different injection sites of low dose botulinum toxin type A with steroid in treating lateral epicondylalgia.
Lateral epicondylalgia or tennis elbow is a common painful elbow disorder with a prevalence of 1% to 3% in the general population and has a higher rate up to 14.5% in strenuous jobs. Botulinum toxin type A injection was an emerging option in treating lateral epicondylalgia. In this study, the patients were randomly assigned into three groups:
The aim of this randomized controlled study was to compare the effects of injection with corticosteroid and botulinum toxin type A via two different sites in patients with lateral epicondylalgia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Botox-Epic group | Experimental | 20 units of Botox injection into lateral epicondyle in Botox-Epic group |
|
| Botox-Tend group | Experimental | 20 units of Botox injected into tender point of muscles in Botox-Tend group |
|
| Steroid group | Active Comparator | 40mg of triamcinolone acetonide but not Botox injected into lateral epicondyle in Steroid group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Botox-Epic | Drug | injected 20 units of Botox into lateral epicondyle in Botox-Epic group |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of pain assessed on the visual analogue scale | baseline, 4 weeks, 8 weeks, 12 weeks, 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change of grip strength by dynamometer | baseline, 4 weeks, 8 weeks, 12 weeks, 16 weeks | |
| Change of self-assessment by Patient-Rated Tennis Elbow Evaluation | baseline, 4 weeks, 8 weeks, 12 weeks, 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yu-Ching Lin, MD, MSc | Contact | 886-6-2353535 | 5258 | richelin@mail.ncku.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Yu-Ching Lin, MD, MSc | National Cheng-Kung University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital | Recruiting | Tainan | Taiwan | 138 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27666156 | Derived | Guo YH, Kuan TS, Chen KL, Lien WC, Hsieh PC, Hsieh IC, Chiu SH, Lin YC. Comparison Between Steroid and 2 Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia: A Randomized, Double-Blind, Active Drug-Controlled Pilot Study. Arch Phys Med Rehabil. 2017 Jan;98(1):36-42. doi: 10.1016/j.apmr.2016.08.475. Epub 2016 Sep 22. |
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| ID | Term |
|---|---|
| D013716 | Tennis Elbow |
| ID | Term |
|---|---|
| D000070639 | Elbow Tendinopathy |
| D052256 | Tendinopathy |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D019274 | Botulinum Toxins, Type A |
| D014222 | Triamcinolone Acetonide |
| D013256 | Steroids |
| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
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| Botox-Tend | Drug | injected 20 units of Botox into tender point of muscles in Botox-Tend group |
|
|
| triamcinolone acetonide (Steroid) | Drug | injected 40mg of triamcinolone acetonide into lateral epicondyle in Steroid group |
|
|
| D000092464 |
| Elbow Injuries |
| D001134 | Arm Injuries |
| D014947 | Wounds and Injuries |
| D013708 | Tendon Injuries |
| D006867 |
| Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |
| D014221 | Triamcinolone |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |