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Three patients were recruited for assessment of ICG fluorescence in burns.
The early determination of healing potential in indeterminate thickness burns may be difficult to establish by visual inspection alone, even for experienced burn practitioners. This case series explores the use of indocyanine green (ICG) fluorescence using portable bedside assessment as a potential tool for early determination of burn depth. Three subjects with indeterminate thickness burns had daily perfusion assessment using ICG fluorescence assessment using the SPY machine (SPY®, Lifecell Corp., NJ, USA) in addition to standard burn care. The fluorescence was quantified as a percentage of the perfusion of intact skin, and areas of hypo and hyper-perfusion were indicated. The burn surgeon, blinded to the ICG results, made a clinical determination of the need for skin grafting or discharge. The perfusion in areas of differing depth of burn were compared over the entire study period to determine both the magnitude of difference, and the point in the time course of healing when these changes became evident.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICG/SPY | Experimental | Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ICG/SPY | Device | indocyanine green fluorescence imaging |
| |
| Antibiotic Ointment |
| Measure | Description | Time Frame |
|---|---|---|
| Perfusion of Burned Area | Perfusion as measured by ICG Fluorescence | 5 days |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27602383 | Result | Dissanaike S, Abdul-Hamed S, Griswold JA. Variations in burn perfusion over time as measured by portable ICG fluorescence: A case series. Burns Trauma. 2014 Oct 25;2(4):201-5. doi: 10.4103/2321-3868.142397. eCollection 2014. |
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| ID | Title | Description |
|---|---|---|
| FG000 | ICG/SPY | Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. ICG/SPY: indocyanine green fluorescence imaging Antibiotic Ointment: Antibiotic ointment |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | ICG/SPY | Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. ICG/SPY: indocyanine green fluorescence imaging Antibiotic Ointment: Antibiotic ointment |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Perfusion of Burned Area | Perfusion as measured by ICG Fluorescence | Posted | Number | % perfusion compared to normal skin | 5 days |
|
Three months
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | ICG/SPY | Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. ICG/SPY: indocyanine green fluorescence imaging Antibiotic Ointment: Antibiotic ointment |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Sharmila Dissanaike | Texas Tech University Health Sciences Center | 8067435609 | sharmila.dissanaike@ttuhsc.edu |
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| ID | Term |
|---|---|
| D002056 | Burns |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| Drug |
Antibiotic ointment |
|
| Participants |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Size of burn | Median | Full Range | % of body surface area |
|
| Patient 2 Superficial |
Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. ICG/SPY: indocyanine green fluorescence imaging Antibiotic Ointment: Antibiotic ointment |
| OG003 | Patient 2 Deep Tissue | Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. ICG/SPY: indocyanine green fluorescence imaging Antibiotic Ointment: Antibiotic ointment |
| OG004 | Patient 3 Superficial | Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. ICG/SPY: indocyanine green fluorescence imaging Antibiotic Ointment: Antibiotic ointment |
| OG005 | Patient 3 Deep Tissue | Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence. ICG/SPY: indocyanine green fluorescence imaging Antibiotic Ointment: Antibiotic ointment |
|
|
| 0 |
| 3 |
| 0 |
| 3 |
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