An simple-blind, randomized study, to evaluate the efficacy and safety of complete closure with clips of mucosal defects after endoscopic mucosal resection (EMR) of large non-pedunculated colorectal lesions (≥ 2 cm) as prophylaxis of delayed bleeding.

Inclusion Criteria:

• 18 years and older
• Clinical indication of endoscopic mucosal resection for large-sized (≥ 2cm) non-pedunculated colorectal lesions.
• Medium-high risk of delayed bleeding (DB risk score ≥ 4)
• Informed consent.

Exclusion Criteria:

• Patients with colorectal non-pedunculated lesions without endoscopic mucosal resection indication.
• Lesions resected by endoscopic submucosal resection.
• Incomplete resections.
• Resections with suspected deep submucosal invasion.
• Mucosal defects treated with clips for known or suspected damage to the muscle layer.
• Lesions with low risk of delayed bleeding (DB risk score ≤3).
• Patients with any other medical, geographic or social condition, deemed by the Investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or interfere with the interpretation of the results.