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| ID | Type | Description | Link |
|---|---|---|---|
| R01AI043596 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| International Centre for Diarrhoeal Disease Research, Bangladesh | OTHER |
| National Institutes of Health (NIH) | NIH |
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The purpose of this study is to explore the role of anti-parasite antibody in protection of children from the parasitic infection cryptosporidiosis. This work has the promise of identifying immune pathways important for protection from parasitic infections of the gut, and will help with designing a vaccine to prevent this infection estimated to cause, from diarrhea and malnutrition, an overall burden of 12 million disability-adjusted life-years in children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children | n=150 | ||
| Mothers | n=150 |
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| Measure | Description | Time Frame |
|---|---|---|
| Functional characterization of anti-Cryptosporidium antibodies associated with protection | Measure antibody isotype and subclass, mucosal (stool) vs systemic (plasma), complement fixation and opsonophagocytosis using bead-based multiplex immunoassays. | Birth until 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| In depth characterization of Cryptosporidium antigens recognized by the child humoral immune response | Utilize this longitudinal study of children and a Cryptosporidium protein microarray to probe plasma for the breadth of antigens recognized as well as the specific antigens to which children respond as they develop protective immunity. | Birth until 4 years. |
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Inclusion Criteria:
Exclusion Criteria:
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Mother-child pairs from the Mirpur Neighborhood of Dhaka, Bangladesh
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The International Centre for Diarrhoeal Disease Research, Bangladesh | Dhaka | Bangladesh |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29514308 | Background | Gilchrist CA, Cotton JA, Burkey C, Arju T, Gilmartin A, Lin Y, Ahmed E, Steiner K, Alam M, Ahmed S, Robinson G, Zaman SU, Kabir M, Sanders M, Chalmers RM, Ahmed T, Ma JZ, Haque R, Faruque ASG, Berriman M, Petri WA. Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing. J Infect Dis. 2018 Jun 20;218(2):259-264. doi: 10.1093/infdis/jiy121. | |
| 29897482 | Background | Steiner KL, Ahmed S, Gilchrist CA, Burkey C, Cook H, Ma JZ, Korpe PS, Ahmed E, Alam M, Kabir M, Tofail F, Ahmed T, Haque R, Petri WA Jr, Faruque ASG. Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study. Clin Infect Dis. 2018 Oct 15;67(9):1347-1355. doi: 10.1093/cid/ciy310. |
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| ID | Term |
|---|---|
| D003457 | Cryptosporidiosis |
| ID | Term |
|---|---|
| D007411 | Intestinal Diseases, Parasitic |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D011529 | Protozoan Infections, Animal |
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| Polymerase chain reaction (PCR) testing for diarrheal pathogens during acute infection | To be conducted on children's acute and convalescent stool during diarrheal episodes. | Birth to 4 years old |
| Determine the role of circulating T follicular helper (cTfh) cells in induction of antibody response | Use Activation Induced Marker (AIM) assays to test parasite infection-dependent changes in the activation, frequency, and immunophenotype of circulating Tfh cells. | Through collection of blood specimens on day 0, 14 and 28 during acute infection. |
| Determination of maternal humoral response and impact on child infection/immunity | Collect mother blood, stool and breast milk on enrollment. Collect second breast milk at 4 months. | On enrollment (all) and 4 months (breast milk only). |
| Surveillance polymerase chain reaction (PCR) testing for diarrheal pathogens | To be conducted on child non diarrheal stool collected twice monthly. | Birth until 4 years. |
| Determine child anthropometric measures | Collect height, weight, mid-upper arm circumference. | Every 6 months until 4 years |
| Socioeconomic status questionnaire | To be conducted on mothers. | At enrollment |
| Household sanitation questionnaire | To be conducted on mothers. | At enrollment |
| 31131855 | Background | Steiner KL, Kabir M, Priest JW, Hossain B, Gilchrist CA, Cook H, Ma JZ, Korpe PS, Ahmed T, Faruque ASG, Haque R, Petri WA. Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study. Clin Infect Dis. 2020 Jan 2;70(2):323-326. doi: 10.1093/cid/ciz430. |
| 33399861 | Background | Donowitz JR, Drew J, Taniuchi M, Platts-Mills JA, Alam M, Ferdous T, Shama T, Islam MO, Kabir M, Nayak U, Haque R, Petri WA. Diarrheal Pathogens Associated With Growth and Neurodevelopment. Clin Infect Dis. 2021 Aug 2;73(3):e683-e691. doi: 10.1093/cid/ciaa1938. |
| 34693912 | Background | Donowitz JR, Pu Z, Lin Y, Alam M, Ferdous T, Shama T, Taniuchi M, Islam MO, Kabir M, Nayak U, Faruque ASG, Haque R, Ma JZ, Petri WA Jr. Small Intestine Bacterial Overgrowth in Bangladeshi Infants Is Associated With Growth Stunting in a Longitudinal Cohort. Am J Gastroenterol. 2022 Jan 1;117(1):167-175. doi: 10.14309/ajg.0000000000001535. |
| 34181697 | Background | Kabir M, Alam M, Nayak U, Arju T, Hossain B, Tarannum R, Khatun A, White JA, Ma JZ, Haque R, Petri WA Jr, Gilchrist CA. Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition. PLoS Pathog. 2021 Jun 28;17(6):e1009445. doi: 10.1371/journal.ppat.1009445. eCollection 2021 Jun. |
| 33684930 | Background | Carey MA, Medlock GL, Alam M, Kabir M, Uddin MJ, Nayak U, Papin J, Faruque ASG, Haque R, Petri WA, Gilchrist CA. Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis. Clin Infect Dis. 2021 Sep 15;73(6):e1242-e1251. doi: 10.1093/cid/ciab207. |
| 37347553 | Background | Gilchrist CA, Campo JJ, Pablo JV, Ma JZ, Teng A, Oberai A, Shandling AD, Alam M, Kabir M, Faruque ASG, Haque R, Petri WA Jr. Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis. J Clin Invest. 2023 Aug 15;133(16):e166814. doi: 10.1172/JCI166814. |
| 40488529 | Derived | Gilchrist CA, Petri WAO, Hossain B, Kabir M, So HH, Moreau GB, Nayak U, Ma JZ, Noor Z, Faruque ASG, Alam M, Haque R, Petri WA Jr. Decrease in Incidence of Diarrhea Due to Cryptosporidium in Bangladeshi Children Is Associated With an Increase in Anti-Cryptosporidium Antibody Avidity. J Infect Dis. 2025 Sep 15;232(3):e362-e371. doi: 10.1093/infdis/jiaf253. |
| 37832036 | Derived | Carey M, Arju T, Cotton JA, Alam M, Kabir M, Faruque ASG, Haque R, Petri WA Jr, Gilchrist CA. Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection. J Infect Dis. 2023 Nov 2;228(9):1292-1298. doi: 10.1093/infdis/jiad257. |
| D010273 | Parasitic Diseases, Animal |
| D003048 | Coccidiosis |
| D011528 | Protozoan Infections |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D000820 | Animal Diseases |