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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
There is a lack of data analyzing the influence of Cardio-vascular Diseases (CVD) risk factor control on graft survival disparities in Black transplant recipients. Studies in the general population indicate that CVD risk factor control is poor in Black patients, leading to higher rates of renal failure and CV events. However, with the exception of hypertension, there is paucity in data demonstrating similar results within transplant recipients. Recent analyses conducted within our transplant program, indicate that CVD risk factors, especially diabetes, are poorly controlled in Black recipients, which likely impacts graft loss. Since these data were collected in a retrospective manner, larger analyses are needed to validate these exploratory findings.
This pilot study is to:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pharmacist-led, technology enabled education intervention | Behavioral | Prospective, non-randomized, pilot study assessing the feasibility and potential efficacy of a 6-month, pharmacist-led, technology enabled education intervention on improving medication safety and cardiovascular risk factor control in adult solitary kidney transplant recipients with a secondary aim of assessing if the impact of the intervention varies by race. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood pressure values from baseline to end of study | Blood pressure will be assessed using clinic measurements, taken three times, five minutes apart in the same arm and averaged. | 6 months |
| Change in HBA1C values from baseline to end of study | 6 months | |
| Change in lipid values from baseline to end of study | 6 months | |
| Medication adherence by comparing medication possession ratios (MPR) for the six months prior to enrollment compared to six months during the intervention | 1 year | |
| Patient self-reported medication adherence at baseline compared to end of study. | The Morisky 8-item adherence score will be compared from baseline to end of study. | 6 months |
| Number of medication errors assessed at baseline and compared to errors at 6 months | 6 months | |
| Medication side effects at baseline compared to end of study. | The Memphis side effect scale will be used to compare side effects from baseline to end of study. | 6 months |
| Patient reported survey results regarding self-care and health knowledge from baseline to end of study | 6 months | |
| Patient reported survey results regarding psychosocial status from baseline to end of study |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30714026 | Derived | Taber DJ, Gebregziabher M, Posadas A, Schaffner C, Egede LE, Baliga PK. Pharmacist-Led, Technology-Assisted Study to Improve Medication Safety, Cardiovascular Risk Factor Control, and Racial Disparities in Kidney Transplant Recipients. J Am Coll Clin Pharm. 2018 Dec;1(2):81-88. doi: 10.1002/jac5.1024. Epub 2018 Jun 21. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D003920 | Diabetes Mellitus |
| D055118 | Medication Adherence |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| 6 months |
| D010349 | Patient Compliance |
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |