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| ID | Type | Description | Link |
|---|---|---|---|
| 2016-A00122-49 | Registry Identifier | ID RCB | |
| RCAPHM16_0010 | Other Identifier | APHM |
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Prematurity tends to increase in France in recent years and more children born extremely premature infants survive. If severe impairments have stabilized, the majority of former extremely premature children have neuropsychological disorders and moderate appearance behavior disorder, but with a significant impact both family, school and social persisting into adulthood.
Executive functions (EF), in general, and working memory (MT), in particular, are frequently altered in older children preterm infants compared to controls born at term.
The identification process of loss in certain diseases, as well as improving knowledge of brain functioning, and development with the possibility of neuronal plasticity has led research teams to develop intervention programs focused on process cognitive qualified of "remediation" cognitive (RC). Schematically, the RC is defined as a rehabilitation or altered cognitive functions. MT can be improved by encouraging the operation of the spots mental stimulant. These programs are effective on MT but do not have the expected impact on other FE, language or nonverbal functions (visuospatial). The functional benefit of cognitive remediation remains controversial.
Improving mental functions untrained as nonverbal MT, attention and secondarily learning is possible but still unproven on wide population. Similarly, randomized trials are needed to test this type of cognitive remediation among preschoolers old very premature.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive remediation parents | Active Comparator |
| |
| Remediation standard | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| computerized cognitive remediation program | Other | a computer program online re-educating the working memory is completed by the parents and the child. The child made a series of interactive exercises accompanied by parents or a practitioner. The exercises are adapted automatically and individually to the performance at each session. |
| Measure | Description | Time Frame |
|---|---|---|
| Increase of the measuring index visuospatial | This index consists of two subtests : block design and object assembly. The average score is 100 with a standard deviation of 15. | 18 months (more or less 2 months) post inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of intellectual functioning | award of global IQ | 8 months (more or less 2 months) post inclusion |
| Evaluation of the working memory | administering the questionnaire Wechsler Preschool and Primary Scale of Intelligence (WPPSI IV) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Urielle DESALBRES, Director | Assistance Publique Hôpitaux de Marseille | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Lyon | Bron | 69677 | France | |||
| University Hospital of Caen Normandie |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37676661 | Derived | Gire C, Beltran Anzola A, Marret S, Foix L'Helias L, Roze JC, Granier M, Patural H, Lecomte B, Guillois B, Souksi Medioni I, Bednarek Weirauch N, Claris O, Hascoet JM, Kuhn P, Zahed M, Boucekine M, Ancel PY, Arnaud C, Cambonie G, Dorriere Datin V; EPIREMED Study Group. Cognitive Training for Visuospatial Processing in Children Aged 5(1/2) to 6 Years Born Very Preterm With Working Memory Dysfunction: A Randomized Clinical Trial. JAMA Netw Open. 2023 Sep 5;6(9):e2331988. doi: 10.1001/jamanetworkopen.2023.31988. | |
| 34517869 |
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|
| standard remediation | Other | A speech therapy and / or academic support is realized. |
|
| 18 months (more or less 2 months) post inclusion |
| evaluation of neuropsychological development of children | award of Neuropsychological Assessment test (NEPSY) | 8 months (more or less 2 months) post inclusion |
| Evaluation of language and skills | passing the test Communicate, Learn to Read and Write (KEY) | 8 months (more or less 2 months) post inclusion |
| Rating behavior | award of Goodman questionnaire (Strengths and Difficulties Questionnaire (SDQ)) | 8 months (more or less 2 months) post inclusion |
| Evaluation of parental anxiety | award of Spielberger Trait Anxiety Inventory questionnaire | 8 months (more or less 2 months) post inclusion |
| Assessing the quality of a child's life | Quality of Life Questionnaire | 8 months (more or less 2 months) post inclusion |
| Evaluation of Education | Evaluation of Education is evaluated by the global adaptation school score (GSA) survey | 8 months (more or less 2 months) post inclusion |
| Caen |
| 14033 |
| France |
| University Hospital of Clermont-Ferrand | Clermont-Ferrand | 63003 | France |
| Sud Francilien Hospital | Corbeil-Essonnes | 91 106 | France |
| University Hospital of Grenoble | Grenoble | 38 043 | France |
| Assistance Publique Hôpitaux de Marseille | Marseille | 13354 | France |
| University Hospital of Montpellier | Montpellier | 34295 | France |
| Regional University Hospital of Nancy | Nancy | 54035 | France |
| University Hospital of Nantes | Nantes | 44093 | France |
| University Hospital of Nice | Nice | 06300 | France |
| University Hospital of Nîmes | Nîmes | 30029 | France |
| AP- HP - Armand Trousseau Hospital | Paris | 75012 | France |
| University Hospital of Reims | Reims | 51092 | France |
| University Hospital of Rouen | Rouen | 76031 | France |
| University Hospital of Saint-Etienne | Saint-Etienne | 42055 | France |
| Regional University Hospital of Strasbourg | Strasbourg | 67200 | France |
| University Hospital of Toulouse | Toulouse | 31059 | France |
| University Hospital of Tour | Tours | 37000 | France |
| Derived |
| Gire C, Beltran Anzola A, Kaminski M, Baumstarck K, Ancel PY, Berbis J; for EPIREMED-Study Group. A randomized EPIREMED protocol study on the long-term visuo spatial effects of very preterm children with a working memory deficit. BMC Pediatr. 2021 Sep 13;21(1):402. doi: 10.1186/s12887-021-02867-x. |