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The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography.
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography. Investigators hypothesize that induced mild hypercarbia (PaCO2 7.5 kPa) cause elevated mean pulmonary arterial pressure and pulmonary vascular resistance, and this reflect to the right ventricle, both volume and function. And this right ventricle effect could be noticed by echocardiography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypercarbia | Experimental | Hypercarbia: PaCO2 is elevated from 5 to 7.5 kPa by controlled ventilation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypercarbia | Procedure | PaCO2 is elevated from 5 to 7.5 kPa by controlled ventilation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Tricuspid annular plane systolic excursion (TAPSE) | TAPSE will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa) | Change from baseline TAPSE at hypercarbia (in approximately 30 min) |
| Mean pulmonary artery pressure (MPAP) | MPAP will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa) | Change from baseline MPAP at hypercarbia (in approximately 30 min) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kati Järvelä, MD | Tampere University Hospital | Principal Investigator |
| Kati Rautaneva, MD | Tampere University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tampere University Hospital Heart Center | Tampere | 33521 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40490845 | Derived | Tujunen MLJ, Lahti J, Kiiski H, Kuitunen AH, Tuohinen SS, Rautaneva K, Jalkanen VL, Huhtala H, Jarvela KM. Right Ventricular Response to Hypercapnia After Mitral Valve Repair: A Hemodynamic Assessment. Acta Anaesthesiol Scand. 2025 Jul;69(6):e70064. doi: 10.1111/aas.70064. |
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| ID | Term |
|---|---|
| D006935 | Hypercapnia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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