To optimize the confirmatory tests for primary aldosteronism.

In this study, the investigators aim to optimize the three confirmatory tests: salt loading, captopril challenge and fludrocortisone suppression, and to confirm a better choice of confirming testing for single or combined diagnosis of primary aldosteronism. Additionally, the investigators plan to collect blood and tissue samples of PA patients for genetic testing, and to proceed a long-term follow-up for further investigating the mechanism underlying PA and evaluating the cardio-cerebrovascular complications risk.

Inclusion Criteria:

• With hypertension;
• With adrenal diseases

Exclusion Criteria:

• Pregnant or during lactation period;
• Under 18 yr;
• BMI ≤ 19 or ≥ 35
• With Cancer medical history
• Been through cardiovascular diseases in the past 3 months;
• Been through malignant arrhythmia, respiratory muscle paralysis or skeletal muscle paralysis caused by hypokalemia.

Group 1: Who was diagnosed with hypertension according to JNC standard and was considered with the possibility of primary aldosteronism.

Group 2: Control Groups, one group for those without hypertension or with primary hypertension; the other group for those with adrenal diseases except for primary aldosteronism.