Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline

Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline

The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance of individuals with subjective cognitive decline.

Memory abilities are known to decline during aging, a process that is accelerated in pathological conditions like subjective, mild cognitive impairment (MCI) and Alzheimer's disease (AD), all of which are a growing public-health concern with devastating effects. Polyamines supplementation and corresponding up-regulation of autophagy (i.e., cellular protein degradation pathways) may be a key target of intervention against age-related memory decline. The study will investigate whether a polyamine-enriched dietary supplementation (through capsule intake) could provide positive effects on the cognitive function of elderly individuals (60-80 years old) with subjective cognitive decline.

Inclusion Criteria:

• Cognitive healthy subjects with subjective memory decline and self-reported concerns
• 60-80 years old
• No manifest dementia (DSM-IV criteria)
• No limitations in activities of daily living
• Capacity for consent

Exclusion Criteria:

• Gluten, histamine or wheat seedling intolerance
• Severe neurological, internal or psychological diseases
• Advanced heart or respiratory diseases, severe arteriosclerosis, untreated thyroid disease or diabetes
• Malignant tumors, current or past history
• Brain tumors, stroke
• Disorders that impair attention
• Dementia
• Coagulation disorder, Marcumar or ASS therapy
• Drug abuse or alcohol dependency
• Current polyamine substitution