Inclusion criteria:
- Healthy Controls: Volunteers (age 18-50 yrs) in generally good Psychiatric and non-Psychiatric medical health
- Borderline Personality Disorder subjects: Research volunteers (age 18-50 yrs) who meet DSM-5 criteria for Borderline Personality Disorder
Exclusion criteria:
All Participants:
- Current medications which affect the central nervous system or vascular activity, such as anti-depressants, anxiolytics, or blood-pressure medications
- Positive urine drug screen for cocaine, opioids, amphetamine, and benzodiazepines
- Positive breathalyzer test for alcohol
- History of clinically significant neurologic disorders or head trauma with loss of consciousness greater than 30 minutes
- Clinically significant non-psychiatric medical disorder requiring ongoing treatment.
- Unwillingness or inability to sign a written informed consent form
- Pregnancy as assessed by a urine test for ß-HCG at each visit
- Medical or physical contraindications for participation based on medical history interview, labs, and physical exam
- Metal fragments or other bodily metal (e.g., pacemaker, orthopedic prosthesis),claustrophobia, or any other condition that would put the subjects at risk for MRI scanning
In addition, Healthy Controls excluded, if:
- DSM-5 diagnoses of Personality Disorders (based on SCID-II)
- DSM-5 diagnoses based on the SCID-I (including the eating disorders module)
- History of arrest or incarceration
In addition, Borderline Personality Disorder Subjects excluded if:
- DSM-5 diagnoses
- DSM-5 Personality Disorder other than Cluster B Personality disorders
- Current psychoactive medications
- Further exclusion criteria apply