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PI left university and IRB protocol closed
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The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
Comparisons will be made between control data and data following a concussion collected from athletes participating in contact-collision sports. For those suffering a concussion, comparisons will be made between day 3 (acute phase), day 21 (recovery phase), and 3 months post-concussion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Subjects who are collegiate level athletes who do not have a concussion and are currently playing a contact-collision sport. | ||
| Concussed | Subjects who have recently suffered a sports-related concussion and are currently a collegiate athlete playing a contact-collision sport. |
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| Measure | Description | Time Frame |
|---|---|---|
| Cerebral blood flow regulation | Subject's cerebral blood flow regulation (cm/sec) at rest, during a cognitive test, and during a breathing test will be measured. | Change in Control, 3 days post concussion, 21 days post concussion, and 3 months post concussion |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Biomarkers | Subjects will have their blood drawn so investigators can look at biomarkers in their blood. The biomarkers will be Tau, a-Spectrin N-Terminal Fragment, Neuron-specific enolase, Ubiquitin C-Terminal hydrolase L1, S100B, and Glial fibrillary acidic protein. | Control, 3 days post concussion, 21 days post concussion, 3 months post concussion |
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Inclusion Criteria:
Exclusion Criteria:
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Collegiate Athletes who are currently playing a contact-collision sport.
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| Name | Affiliation | Role |
|---|---|---|
| Sushmita Purkayastha, Ph.D | Southern Methodist University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Southern Methodist University | Dallas | Texas | 75205 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30729729 | Derived | Purkayastha S, Adair H, Woodruff A, Ryan LJ, Williams B, James E, Bell KR. Balance Testing Following Concussion: Postural Sway versus Complexity Index. PM R. 2019 Nov;11(11):1184-1192. doi: 10.1002/pmrj.12129. Epub 2019 Apr 3. |
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| ID | Term |
|---|---|
| D001924 | Brain Concussion |
| D038223 | Post-Concussion Syndrome |
| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Memory Function Test | Subjects will be given paper tests to test their memory function. | Control, 3 days post concussion, 21 days post concussion, 3 months post concussion |
| Balance Test | Subjects balance will be measured using a force plate. | Control, 3 days post concussion, 21 days post concussion, 3 months post concussion |
| Orthostatic Tolerance Test | Subjects physiological measurements will be measured as the move from a seated position to a standing position. | Control, 3 days post concussion, 21 days post concussion, 3 months post concussion |
| Cerebral Vasoreactivity | Subjects will breathe normal air, a 8% carbon dioxide gas mixture, and hyperventilate. | Control, 3 days post concussion, 21 days post concussion, 3 months post concussion |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D016489 | Head Injuries, Closed |
| D014947 | Wounds and Injuries |
| D014949 | Wounds, Nonpenetrating |