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The overall objective of this study is to observe the effect of group Vocal performance training and performance experience on patients' reported symptoms and quality of life. The effectiveness of PD medications varies significantly in different patients depending on their symptoms. By using music-based interventions to improve symptoms that may be inadequately treated by medications, the investigators hope to improve quality of life in PD patients. "Parkinsonics: A controlled study of group singing for quality of life and voice outcomes in Parkinson disease" (PD) is a controlled crossover behavioral intervention study of once weekly choral classes for patients with idiopathic PD (progressing toward a group performance) and once weekly discussion/support group meetings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Singing Intervention | Experimental | Twelve weekly group singing classes lasting 60-90 minutes under the direction of a professional choir director and a social worker with a music background. |
|
| Discussion/Support Group Intervention | Active Comparator | Twelve weekly 60-90 minute discussion groups led by a facilitator trained in discussion group facilitation; occurring at the same time and in the same location (next door) as experimental intervention (group singing). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group singing | Behavioral | Weekly group singing classes led by professional choir instructor, lasting 90 minutes. 12 classes over 12 consecutive weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Parkinson Disease Quality of Life Questionnaire (PDQ)-39 scores | Validated 39-item questionnaire | Change from baseline scores at 30 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Voice-Related Quality of Life | Validated 10-item questionnaire | Change from baseline scores at 30 weeks |
| Movement Disorder Society-Unified Parkinson Disease Rating Scale Motor scores | Validated Parkinson disease motor assessment scale |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility | At least 80% of participants attending at least 9 of 12 singing classes and the final performance | 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexander Pantelyat, MD | Johns Hopkins University | Principal Investigator |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Facilitated Discussion Group | Behavioral | Weekly facilitated discussion group led by Parkinson Disease educator, lasting 90 minutes. 12 sessions over 12 consecutive weeks. |
|
| Change from baseline scores at 30 weeks |
| Montreal Cognitive Assessment | Validated cognitive assessment | Change from baseline scores at 30 weeks |
| Geriatric Depression Scale-15 | Validated depression self-rating | Change from baseline scores at 30 weeks |
| Lorig Self-efficacy scale | 5-item self-reported questionnaire | Change from baseline scores at 30 weeks |
| Short Form-36 | Self-reported questionnaire assessing patients' health based on their physical and mental well-being | Change from baseline scores at 30 weeks |
| Sound pressure level (decibels) | Assessed while reading the standardized "Rainbow" passage and describing the cookie theft picture at a 50cm distance from the microphone (using a portable professional decibel meter). | Change from baseline levels at 30 weeks |
| Voice jitter | Analysis will be performed using Praat software (Boersma and Weenink, version 5.4.01, http://www.fon.hum.uva.nl/praat/). There will be 3 trials per subject holding sounds A and E for as long as possible on one breath. Sound recordings are made for each trial. | Change from baseline values at 30 weeks |
| Voice shimmer | Analysis will be performed using Praat software (Boersma and Weenink, version 5.4.01, http://www.fon.hum.uva.nl/praat/). There will be 3 trials per subject holding sounds A and E for as long as possible on one breath. Sound recordings are made for each trial. | Change from baseline values at 30 weeks |
| Harmonic to noise ratio | Analysis will be performed using Praat software (Boersma and Weenink, version 5.4.01, http://www.fon.hum.uva.nl/praat/). There will be 3 trials per subject holding sounds A and E for as long as possible on one breath. Sound recordings are made for each trial. | Change from baseline values at 30 weeks |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |