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Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The objective of this study is to evaluate the potential functional benefice of these compensatory movements in a population of 20 patients with chronic bilateral areflexia, in a cross-sectional study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bilateral vestibular hypofunction | Experimental | Patients suffering from chronic bilateral vestibular hypofunction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Head Impulse Tests | Other | Head Impulse Tests are performed by the clinician who holds the patient's head in his hands, while he is looking straight at an earth-fixed target; then by turning the patient's head abruptly and unpredictably to the left or right, up or down through a small angle (only 10-20 degrees - not a large angle). 20 impulses in each directions (6) will be performed. |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of covert-saccades | Frequency of covert saccades corresponds to the total amount of covert-saccades divided by the total amount of head impulse tests multiplied by 100. | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life assessed with the Dizziness Handicap Inventory | Dizziness Handicap Inventory is a questionnaire that identify difficulties that patient may be experiencing because of dizziness, yielding to a score ranging from 0 to 100 | Day 0 |
| Dynamic visual acuity |
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Inclusion Criteria:
Bilateral Vestibular Hypofunction (BVH) with at least two of the tree following criteria
Disorder present for over 6 month
Comprehension of the experiments instructions
Patient consent
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Caroline TILIKETE, MD | Institut National de la Santé Et de la Recherche Médicale, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Unité de Neuro-Ophtalmologie Hôpital Neurologique | Bron | 69500 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29248983 | Result | Hermann R, Pelisson D, Dumas O, Urquizar C, Truy E, Tilikete C. Are Covert Saccade Functionally Relevant in Vestibular Hypofunction? Cerebellum. 2018 Jun;17(3):300-307. doi: 10.1007/s12311-017-0907-0. |
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| ID | Term |
|---|---|
| D015837 | Vestibular Diseases |
| ID | Term |
|---|---|
| D007759 | Labyrinth Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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|
| Dynamic visual acuity Test (DVAT) | Other | Dynamic visual acuity Test (DVAT) assesses visual acuity during head movement relative to baseline static visual acuity. DVA will be assessed actively during self-generated rotations of the head in different directions. |
|
| VEMPs & VEMPo | Other | VEMPs & VEMPo are sound evoked muscular contractions of the neck or eye. They are recorded using an evoked response computer, a sound generator, and surface electrodes to pick up neck or eye muscle activation. |
|
| Dizziness Handicap Inventory | Other | Dizziness Handicap Inventory is a questionnaire that identify difficulties that patient may be experiencing because of dizziness, yielding to a score ranging from 0 to 100 |
|
| Oscillopsia severity questionnaire | Other | Oscillopsia severity questionnaire is a 9 items questionnaires that identify oscillopsia in different circumstances. |
|
Dynamic visual acuity is a measure of threshold for binocular reading of letters that are presented on a screen during head impulse test |
| day 0 |
| Oscillopsia severity questionnaire score | Oscillopsia severity questionnaire is a 9 items questionnaires that identify oscillopsia in different circumstances. A mean item score gives an oscillopsia severity score ranging from 1 to 5, yielding to a total score ranging from 0 to 45 | day 0 |
| Latency of covert-saccades | Latency of covert saccades correspond to the time between the beginning of head impulse and the initiation of the first covert-saccade | Day 0 |