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Dental caries is a multifactorial disease effecting majority of the human population.One of the etiological factor causing dental caries is salivary mutans streptococci. Reducing the levels of this bacteria in the saliva can significantly reduce the incidence of dental caries. A non-invasive intervention, such as the administration of probiotics reduced the salivary mutans streptococci levels.
40 candidates were selected from a pre-determined group and were randomly assigned to two groups. Group A (n=20) was administered probiotic drink and Group B (n=20) was administered placebo for 14 consecutive days. Saliva was collected on day 1 and day 15 to compare the salivary mutans streptococci levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| probiotic | Experimental | 2 mg of probiotic powder mixed in 10 ml of distilled water |
|
| placebo | Placebo Comparator | 10 ml of distilled water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| probiotic | Biological | Probiotic was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| counts of streptococcus mutans after the consumption of probiotic | Human saliva was assessed for the counts of streptococcus mutans, one of the major etiological factor for dental caries | 15 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| G. RATNA VELUGU, MDS | Sharda University | Principal Investigator |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 11, 2016 | |
| Reset | Jun 16, 2016 | |
| Release | Jun 18, 2016 | |
| Reset | Jul 28, 2016 | |
| Release | Apr 28, 2017 | |
| Reset | Jun 6, 2017 | |
| Release | Jul 18, 2017 | |
| Reset | Jul 18, 2017 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 11, 2016 | Jun 16, 2016 | |||
| Jun 18, 2016 |
| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| C562118 | exopolysaccharide biopolymer, Bacillus coagulans |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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|
| placebo | Other | placebo was administered for a period of 14 consecutive days. Saliva was collected on Day 1, before intervention and on Day 15, after intervention |
|
| Jul 28, 2016 |
| Apr 28, 2017 | Jun 6, 2017 |
| Jul 18, 2017 | Jul 18, 2017 |
| D019602 |
| Food and Beverages |