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300 recurrent implantation failure patients will be alternatively assigned to assisted hatching , endometrial scratch , and no treatment ,100 patients in each group
Group 1 consists of 100 patients will undergo endometrial scratch followed by controlled ovarian hyperstimulation Group 2 consists of 100 patients will undergo controlled ovarian hyperstimulation& assisted hatching Group 3 consists of 100 patients will undergo controlled ovarian hyperstimulation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endometrial scratch group | Active Comparator | endometrial scratch controlled ovarian hyperstimulation |
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| Assisted hatching group | Active Comparator | assisted hatching controlled ovarian hyperstimulation |
|
| ovarian stimulation only group | Sham Comparator | controlled ovarian hyperstimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endometrial scratch | Procedure | midluteal endometrial scratch using Novak curette under general anesthesia in the cycle preceding stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| number of patients with positive pregnancy test | 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| suzy abdelaziz, lecturer | Contact | 01003726195 | suzyabdelaziz92@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| suzy abdelaziz, lecturer | kasrelaini hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33730422 | Derived | Lacey L, Hassan S, Franik S, Seif MW, Akhtar MA. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)). Cochrane Database Syst Rev. 2021 Mar 17;3(3):CD001894. doi: 10.1002/14651858.CD001894.pub6. |
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|
| assisted hatching | Procedure | using Octax laser 20120644-laser 5452 |
|
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| controlled ovarian hyperstimulation | Procedure | using merional&/ or fostimon doses individualized as judged by patient age & ovarian reserve & monitored by follicular size & serum estradiol |
|