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Ametop was introduced into the formulary as it was deemed more efficacious for intravenous cannulation compared to EMLA. However, the incidences of adverse reactions seemed to be higher compared to other studies. This lead to a prospective observational study to look at the incidence and severity of skin reactions following routine clinical application of Ametop.
Ametop was introduced into the formulary as it was deemed more efficacious for intravenous cannulation compared to EMLA. After several critical incidences of adverse reactions that occurred with its application, a departmental audit was carried out to look at the incidence and severity reactions with its application as well as its outcome on intravenous cannulation. The findings of the departmental audit showed that the incidence of adverse reactions seemed to occur more commonly compared to other studies.
A prospective observational study was carried out to look at the incidence and severity of skin reactions following routine clinical application of Ametop.
This study aims to achieve the following:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tetracaine | Drug | Application of Ametop prior to intravenous cannulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of skin reactions with Ametop | looking at the incidence of skin reactions with Ametop - normal, simple erythema, raised erythema, itch, pallor | October 2014 to May 2015 |
| Measure | Description | Time Frame |
|---|---|---|
| Risk factors associated with incidence of skin reactions | Looking at possible factors associated with skin reactions - race, duration of application, history of atopy | October 2014 to May 2015 |
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Inclusion Criteria:
Exclusion Criteria:
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Paediatric patients presenting for surgery in KK Women's and Children's Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Angela YJ Tan, MMed | KK Women's and Children's Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10566919 | Background | Browne J, Awad I, Plant R, McAdoo J, Shorten G. Topical amethocaine (Ametop) is superior to EMLA for intravenous cannulation. Eutectic mixture of local anesthetics. Can J Anaesth. 1999 Nov;46(11):1014-8. doi: 10.1007/BF03013194. | |
| 10735838 | Background | Arrowsmith J, Campbell C. A comparison of local anaesthetics for venepuncture. Arch Dis Child. 2000 Apr;82(4):309-10. doi: 10.1136/adc.82.4.309. |
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Data will be protected and not shared.
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| ID | Term |
|---|---|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
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| ID | Term |
|---|---|
| D013748 | Tetracaine |
| ID | Term |
|---|---|
| D062366 | para-Aminobenzoates |
| D062365 | Aminobenzoates |
| D001565 | Benzoates |
| D000146 | Acids, Carbocyclic |
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| D002264 |
| Carboxylic Acids |
| D009930 | Organic Chemicals |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |