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| Name | Class |
|---|---|
| Zhujiang Hospital | OTHER |
| Nanfang Hospital, Southern Medical University | OTHER |
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Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. However the EP information mainly based on ex vivo measurement of cancer tissues, and few data in vivo were published. The purpose of this study is to in vivo measure the electrical properties of the malignant tissues.
The measurements were safety guaranteed and were conducted during the cancer surgeries. Before the tissue was excised from the patient,the pathologist assisted the operator (already at the operating room) responsible for the measurement.The measurement of malignant and corresponding normal tissues were both performed. The tissues for dielectric properties measurement were classified as normal or malignant by the pathologist based on his own expertise and decision criteria (visual inspection, anatomy) and the per-operative histological examination. The measurements were directly performed on the tissue before excision.The sites of the measured malignant tissues were marked,doubletracked according to the pathological report to make sure the marked sites are malignant. The patient age and tissue temperature at the time of measurement were recorded.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| network analyzer | Device | The dielectric properties of the tissues were measured using the open-ended coaxial line method. The measurement system consisted of a network analyzer (Model 4395A, Agilent Corp., Santa Clara, CA) associated with an S-parameter test set (Model 87511A, Agilent Corp., Santa Clara, CA). A semi-rigid coaxial line with a diameter of 3.58 mm was connected to the network analyzer system by using a Bayonet Neill-Concelman connector. The other tip of the coaxial line (probe) was placed on the flat bare surface of the tissue. |
| Measure | Description | Time Frame |
|---|---|---|
| Conductivity of the Malignant Tissues measured In Vivo | one year | |
| Relative Permittivity of the Malignant Tissues measured In Vivo | one year |
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Inclusion Criteria:
Exclusion Criteria:
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The patients who are diagnosed with cancer disease and about to have an operation to excise the cancer tissues.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sherman X Xin, professor | Contact | 008613602733465 | xxg@smu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Sherman X Xin, professor | School of Biomedical Engineering,Southern Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Southern medical university | Guangzhou | Guangdong | 510515 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Athey T W, Stuchly M A and Stuchly S S. Measurement of radio frequency permittivity of biological tissues with an open-ended coaxial line: Part I. Microwave Theory and Techniques, IEEE Transactions on IEEE Trans 30(1): 82-86, 1982. | ||
| Background | Bobowski Jake S, Johnson Thomas. Permittivity measurements of biological samples by an open-ended coaxial line. Progress In Electromagnetics Research B 40: 159-183, 2012. | ||
| 2834285 | Background | Surowiec AJ, Stuchly SS, Barr JB, Swarup A. Dielectric properties of breast carcinoma and the surrounding tissues. IEEE Trans Biomed Eng. 1988 Apr;35(4):257-63. doi: 10.1109/10.1374. No abstract available. | |
| 3710509 |
| Label | URL |
|---|---|
| An Internet resource for the calculation of the dielectric properties of body tissues in the frequency range 10 Hz - 100 GHz Based on data published by C.Gabriel et al. in 1996. | View source |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| Background |
| Smith SR, Foster KR, Wolf GL. Dielectric properties of VX-2 carcinoma versus normal liver tissue. IEEE Trans Biomed Eng. 1986 May;33(5):522-4. doi: 10.1109/TBME.1986.325740. No abstract available. |
| Background | Mehta P, Chand K, Narayanswamy D, Beetner D G, Zoughi R and Stoecker W V. Microwave reflectometry as a novel diagnostic tool for detection of skin cancers IEEE Trans. Instrum. Meas. 55: 1309-16, 2006 |