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| Name | Class |
|---|---|
| University of Milano Bicocca | OTHER |
The Ability research project, funded in Italy within the Smart Cities and Smart Communities funding program (MInistry of University and Research, Operational Regional Programme, Lombardy, Axis 1, Operational Regional Programme - European Funding for Regional Development 2007-2013), aims at developing and testing the efficacy and the impact of a Personal Smart Health Community able to provide innovative trajectories for people with cognitive impairment, putting them at the core of a continuous and intertwining treatment and support from both formal (e.g. physicians) and informal (e.g. near relatives) caregivers, with special focus on home-based care.
Within this framework of the Ability project the investigators test the efficacy of the home-based motor-cognitive rehabilitation program delivered with two different approaches: the Ability platform versus the usual care program
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ability platform program | Experimental | Multi-domain at home rehabilitation program delivered through the Ability platform. |
|
| Usual care program | Active Comparator | Usual care at home program (paper and pencil cognitive activities; promotion of physical activity according to healthcare professional's advice) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ability platform program | Other | The Ability program is an at home participant-tailored and technology-enhanced platform a) delivering tablet-based intensive (five days/a week for six weeks) motor and cognitive activities; b) monitoring from remote vital and physical health parameters (i.e., weight, Heart Rate, O2 saturation, daily steps, sleep activity). |
| Measure | Description | Time Frame |
|---|---|---|
| activities of daily living | Activities of Daily Living Inventory (ADCS/ADL) | change from baseline after 8 weeks (aMCI/AD subjects) |
| behavioral symptoms | Neuropsychiatric Inventory (NPI) score | change from baseline after 8 weeks (aMCI/AD subjects) |
| cognitive domain (long-term memory) | Free and Cued Selective Recall Test (FCSRT) score | change from baseline after 8 weeks (aMCI/AD subjects) |
| cognitive domain (language) | Fluency score | change from baseline after 8 weeks (aMCI/AD subjects) |
| cognitive domain (frontal-executive functions) | Trail Making Test (TMT) score | change from baseline after 8 weeks (aMCI/AD subjects) |
| quality of life | Dementia Quality of Life (D-QoL) Instrument | change from baseline after 8 weeks (aMCI/AD subjects) |
| coping strategies | Coping Orientation for Problems Experienced - Brief Version (Brief COPE) | change from baseline after 8 weeks (aMCI/AD subjects) |
| global cognitive level | Montreal Cognitive Asssessment (MoCA) score |
| Measure | Description | Time Frame |
|---|---|---|
| activities of daily living | Activities of Daily Living Inventory (ADCS/ADL) | change from baseline after 12 months (aMCI/AD subjects) |
| conversion rate MCI versus AD | conversion rate score |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21514249 | Background | Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):270-9. doi: 10.1016/j.jalz.2011.03.008. Epub 2011 Apr 21. | |
| 27887597 |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D003704 | Dementia |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
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|
| Usual care program | Other | Usual care at home program (paper and pencil cognitive activities; promotion of physical activity according to healthcare professional's advice) |
|
| change from baseline after 12 months (aMCI/AD subjects) |
| change from baseline after 12 months (aMCI subjects) |
| cognitive domain - long term memory | Free and Cued Selective Recall Test (FCSRT) score | change from baseline after 12 months (aMCI/AD subjects) |
| cognitive domain - language | Fluency score | change from baseline after 12 months (aMCI/AD subjects) |
| cognitive domain - frontal executive functions | Trail Making Test (TMT) score | change from baseline after 12 months |
| quality of life | Dementia Quality of Life (D-QoL) Instrument | change from baseline after 12 months |
| coping strategies | Coping Orientation for Problems Experienced - Brief Version (Brief COPE) | change from baseline after 12 months |
| caregiver quality of life | Psychological Well-Being (PWB) scale | change from baseline after 8 weeks and after 12 months |
| caregiver coping strategies | Coping Orientation for Problems Experienced - Brief Version (Brief COPE) | change from baseline after 8 weeks and after 12 months |
| caregiver burden | Caregiver Burden Inventory (CBI) | change from baseline after 8 weeks and after 12 months |
| caregiver affect | Positive and Negative Affect Schedule (PANAS) | change from baseline after 8 weeks and after 12 months |
| Derived |
| Realdon O, Rossetto F, Nalin M, Baroni I, Cabinio M, Fioravanti R, Saibene FL, Alberoni M, Mantovani F, Romano M, Nemni R, Baglio F. Technology-enhanced multi-domain at home continuum of care program with respect to usual care for people with cognitive impairment: the Ability-TelerehABILITation study protocol for a randomized controlled trial. BMC Psychiatry. 2016 Nov 25;16(1):425. doi: 10.1186/s12888-016-1132-y. |
| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |