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This trial is conducted in China. The aim of this trial is to assess the safety and tolerability for Multiple s.c injection of HS-20004 in healthy Chinese subjects
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental 1 | Experimental | Once daily subcutaneous dose for 7 Days of HS-20004 0.02 mg or Matched Placebo. |
|
| Experimental 2 | Experimental | Once daily subcutaneous dose for 7 Days of HS-20004 0.04 mg or Matched Placebo. |
|
| Experimental 3 | Experimental | Once daily subcutaneous dose for 7 Days of HS-20004 0.06 mg or Matched Placebo. |
|
| Experimental 4 | Experimental | Once daily subcutaneous dose for 7 Days of HS-20004 0.08 mg or Matched Placebo. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HS-20004 | Drug |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Number of treatment emergent adverse events (TEAEs) | Day 0 and up to 3 days after last treatment (Day 10) |
| Measure | Description | Time Frame |
|---|---|---|
| Area under the plasma HS-20004 concentration curve after the last s.c injection | Time 0 to 72 hours after the last dose | |
| Peak plasma concentration (Cmax) after the last dose | Time 0 to 72 hours after the last treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Drug |
|
| Terminal elimination half-life (t½) for HS-20004 after the last dose | Time 0 to 72 hours after the last treatment |
| Change in 24-hour profiles of plasma glucose and serum insulin from baseline | From time 0 to 24 hours after the first and last treatment |