Oxytocin Effects on Likeability After Being Liked or Disl... | NCT02745431

Studies
Oxytocin Effects on Likeability After Being Liked or Disliked

NCT02745431

Sponsor

University of Electronic Science and Technology of China

Status

Completed

Last Update Posted

Aug 1, 2017Actual

Enrollment

86Actual

Phase

Not Applicable

Conditions

Social Behavior

Interventions

Oxytocin
Placebo

Countries

China

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Nov 2016

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jun 2015

Primary Completion Date

Jun 2016Actual

Completion Date

Jun 2016Actual

First Submitted Date

Apr 15, 2016

First Submission Date that Met QC Criteria

Apr 15, 2016

First Posted Date

Apr 20, 2016Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jul 29, 2017

Last Update Posted Date

Aug 1, 2017Actual

Description Module

Brief Summary

The current study aimed to investigate oxytocin effect on the response after the experience of being liked or disliked.

Detailed Description

In a double-blind, between-subject, placebo controlled design study, the researchers aimed to investigate the intranasal OXT (40IU) treatment on rating response after being liked or disliked in healthy male subjects. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS),Autism Spectrum Quotient (ASQ), Empathy Quotient(EQ) before self-administration.Study participants were led to believe that other participants had formed an opinion on their likability based on their appearance in a photograph and they passively viewed the responses (like or dislike) from 'other participants'. After that, they rated 'other participants' about likeability (how much do you like the person), accuracy (have you seen the person), feeling (how good do you feel), and tendency (how much would do like have him/her as a friend). Likeability, tendency, feeling and accuracy were included into analysis as dependent variables.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

86Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Oxytocin nasal spray	Experimental	Oxytocin nasal spray	Drug: Oxytocin
Placebo nasal spray	Placebo Comparator	Placebo nasal spray	Drug: Placebo

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Oxytocin	Drug		Oxytocin nasal spray
Placebo

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Oxytocin effect on likeability after being liked or disliked	Likeability rating was included into analysis as dependent factor.	2 hour

Secondary Outcomes

Measure	Description	Time Frame
Relationship status may influence oxytocin effect	subjects were subdivided into two subgroups	2 hour

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Healthy subjects without past or current psychiatric or neurological disorder

Exclusion Criteria:

history of head injury;
claustrophobia;
medical or psychiatric illness.

Accepts Healthy Volunteers

Yes

Sex

Male

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

30 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
School of Life Science and Technology, University of Electronic Science and Technology		Chengdu	Sichuan	611731	China

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
29304421	Derived	Zhao W, Ma X, Le J, Ling A, Xin F, Kou J, Zhang Y, Luo R, Becker B, Kendrick KM. Oxytocin biases men to be more or less tolerant of others' dislike dependent upon their relationship status. Psychoneuroendocrinology. 2018 Feb;88:167-172. doi: 10.1016/j.psyneuen.2017.12.010. Epub 2017 Dec 22.

ID	Term
D010909	Pituitary Hormones, Posterior
D010907	Pituitary Hormones
D036361	Peptide Hormones
D006728	Hormones