Physiologic Study of Cerebral Perfusion | NCT02744625 | Trialant

Physiologic Study of Cerebral Perfusion | NCT02744625 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Shock lower Mean Arterial Pressure (MAP)	Active Comparator	Vasopressor-dependent treated to lower MAP (65 mmHg)	Drug: Lower doses of vasopressor therapy for a MAP of 65 mmHg Drug: Propofol for light sedation
Shock higher MAP	Experimental	Vasopressor-dependent treated to higher MAP (75 mmHg)	Drug: Higher doses of vasopressor therapy for a MAP of 75 mmHg Drug: Propofol for light sedation
Healthy participant awake	No Intervention	Healthy participant awake
Healthy participant sedated	Experimental	Healthy participant Under light sedation	Drug: Propofol for light sedation

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Global and regional cerebral blood flow	Cerebral blood flow will be measured by the arterial spin labeling technique (ASL) which provides information expressed in mL/100g/min. Using 3-T MRI technology,we will first acquire T1 images of the brain and sub-regions of interest. Thereafter, ASL sequences will be acquired in contiguous slices. The procedure will be followed on sedation and off sedation for healthy volunteers (in random order) and at mean arterial pressure of 65 mmHg and 75 mmHg (in random order) in patients receiving vasopressor therapy.	Within 15 minutes of intervention initiation

Contacts/Locations Module