Physiologic Study of Cerebral Perfusion

Physiologic Study of Cerebral Perfusion

The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients

Healthy Subjects :

• Inclusion criteria :

  • being over 18 years old

• Exclusion criterias :

  • having a positive serum pregnancy test
  • having a contraindication to MRI
  • having a contraindication to receive light sedation with propofol
  • suffering of claustrophobia or of anxiety disorder

Shock Subjects :

• Inclusion criterias :

  • being over 18 years old
  • being hospitalized to the medical intensive care unit of the CHUS Fleurimont
  • being in a stabilized shock state, primarily of distributive etiology
  • having received an appropriate fluid resuscitation, as judged by the attending physician

• Exclusion criterias :

  • having a different primary etiology of shock than distributive (cardiogenic, hypovolemic, obstructive)
  • needing vasopressor therapy as the result of extracorporeal circulation
  • having known cerebral lesions
  • having an intra-aortic balloon pump
  • being in a palliative or near end-of-life situation
  • having a contraindication to MRI
  • suffering of claustrophobia or of anxiety disorder