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| ID | Type | Description | Link |
|---|---|---|---|
| MUH20167 | Registry Identifier | Minia University |
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study the effect of aromataze inhibitor induction together with short stimulation protocol by gonadotrphin releasing hormon antagonist in cases that expected to be poor responder before ICSI
This is a prospective randomized case control study will be conducted in Maternity hospital IVF unite Minia University after being approved by local ethical committee of obstetrics and gynecology department faculty of medicine, all study details will be explained to patients and informed consent will be obtained before inclusion in the study . enrolled patients will be randomized into two groups using simple randomization by sealed opaque envelops contain serial computer generated numbers Control group will receive HMG 300 IU daily start at first day of menses with follow up by trans vaginal ultrasound (TVUS ) when at least three follicles reach 14mm diameter GnRh antagonist given 0.1 ml continue follow up when at least three follicles reach 17mm in diameter ovum pickup will done under TVUS guide if less than three follicles cycle will be cancelled .
Study group will receive same management plus letrozole 2.5mg daily start at the first day of menses for 5 days and continue with same protocol
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| aromataze group | Experimental | patients will receive induction with HMG plus aromataze inhibitor plus GnRh antagonist plus HCG injection |
|
| classic group | Active Comparator | same protocol for induction without aromataze inhibitor |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| induction with aromataze inhibitor | Drug | letrozole 2.5mg once daily start in the first day of menses for 5days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of follicles per cycle that reach more than 17mm in diameter(quantity of ova) | measurement of the diameter of follicles by transvaginal ultrasoundand description of diameter in report | day of HCG injection |
| quality of ova | After ova picking up examination of all ova under microscope and report how many ova reach metaphase II (quality) if more than 3 ova reach metaphase II considered satisfactory quality of ova in the current cycle | day of ovum pick up |
| Measure | Description | Time Frame |
|---|---|---|
| pregnancy rate | presence of clinical pregnancy | 14 days after ovum pick up |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Minia University | Minya | Minya Governorate | 61519 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11937133 | Result | Mitwally MF, Casper RF. Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. Fertil Steril. 2002 Apr;77(4):776-80. doi: 10.1016/s0015-0282(01)03280-0. |
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| HMG | Drug | HMG 300 IU injection once daily start at first day of menses with follow up by trans vaginal ultrasound (TVUS ) till at least three follicles reach 14 mm in diameter |
|
|
| GnRh a | Drug | antagonist given 0.1 ml injection once daily with continous follow up when at least three follicles reach 17mm in diameter HCG 10.000 IU injection and ovum pick up 24-36hours after injection |
|
|
| HCG | Drug | 10.000 IU HCG injection when at least three follicles reach 17mm in diameter |
|
|
| ID | Term |
|---|---|
| D020360 | Neoadjuvant Therapy |
| D000077289 | Letrozole |
| C527545 | hMG-IBSA |
| C090784 | ricin A-GnRH conjugate |
| D017329 | Triptorelin Pamoate |
| ID | Term |
|---|---|
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D009570 | Nitriles |
| D009930 | Organic Chemicals |
| D014230 | Triazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D007987 | Gonadotropin-Releasing Hormone |
| D010906 | Pituitary Hormone-Releasing Hormones |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
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