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Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm &with or without GnRh agonists for all endometrioma patients
Group 1 consists of 30 patients of endometrioma more than 5cm subdivided into:
Group 1A;Cyst aspiration followed by standard long protocol in 15 patients Group 1B;Cyst aspiration followed by GnRh suppression for 3 months then standard long protocol in 15 patients
Group 2 consists of 30 patients of endometrioma less than 5cm subdivided into :
Group 2A;no intervention to the cyst. Standard long protocol Group 2B;GnRh suppression for 3 months then standard long protocol
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1A endometrioma more than 5cm | Active Comparator | Endometrioma aspiration GnRh agonist :Decapeptyl 3.75mg intramuscular Standard long stimulation protocol & ICSI |
|
| 1B endometrioma more than 5cm control | Sham Comparator | Endometrioma aspiration Standard long stimulation protocol & ICSI |
|
| 2A endometrioma less than 5cm | Active Comparator | Decapeptyl 3.75mg intramuscular Standard long stimulation protocol & ICSI |
|
| 2B endometrioma less than 5cm control | Sham Comparator | Standard long stimulation protocol & ICSI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endometrioma aspiration | Procedure | Transvaginal ultrasound guided aspiration |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with urine pregnancy test positive 2 weeks after embryo transfer | 5 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| suzy abdelaziz, lecturer | Kasr El Aini Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kasrelaini Hospital | Giza | Egypt |
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| ID | Term |
|---|---|
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D007987 | Gonadotropin-Releasing Hormone |
| D017329 | Triptorelin Pamoate |
| ID | Term |
|---|---|
| D010906 | Pituitary Hormone-Releasing Hormones |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| GnRh agonist ( Decapeptyl ) | Drug | 3 monthly doses of Decapeptyl 7.5mg intramuscular |
|
|
| standard long stimulation protocol | Procedure | Decapeptyl 3.75mg in the mid luteal phase followed by human menopausal gonadotropins(HMG);fostimon, or merional injections after bleeding, doses are individualization according to each patient, monitored by follicular size &serum estradiol. |
|
| D000091662 | Genital Diseases |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |