Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Oslo | OTHER |
| Hasselt University | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aims of the current study is to explore if different exercise training protocols affect fatigue post-exercise, and if sarcoidosis-related fatigue and maximal and sub-maximal cardiopulmonary exercise test (CPET) variables change after a 4-weeks exercise training period.
This project aims to provide data on post-exercise fatigue after single exercise sessions with endurance training and muscle strength training, each with two different intensities. For endurance training; post-exercise fatigue will be assessed after one session of high intensity interval training, and one session with longer duration of moderate intensity. For muscle strength training, fatigue will be measured after one session with high loads/few repetitions and one session with low loads/many repetitions. In addition, changes in sub-maximal and maximal metabolic and ventilatory responses to a maximal cardiopulmonary exercise test on a treadmill (CPET) and association to sarcoidosis-related fatigue before and after a 4-weeks exercise training period will be studied.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise training | Experimental | Four exercise training sessions. Two endurance training sessions, one with high intensity interval training and one session of moderate intensity of longer duration. Two strength training session; one with high load and few repetitions and one with low load and many repetitions. Fatigue and lactate will be measured before, after and 24 hours post-exercise. Trainings sessions will be randomized. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Muscle strength training | Other | Two different muscle strength training protocols will be compared; one exercise session with high load/low repetitions (4 sets x 5RM) versus one exercise session with low load/high repetitions (2 sets x 25RM). Both session will be conducted at four different exercises; seated leg press, chest press, cable lat pull down and seated rowing. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in fatigue | Changes of fatigue will be assessed assessed by Visual Analogue Scale (VAS), where the grade of fatigue is assessed between 0 (no fatigue) and 10 (maximal fatigue). | Fatigue measured immediately before and acute after exercise sessions, (within 1 min.), and addition 24 hours post-exercise. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood lactate | Blood lactate will be assessed by capillary puncture in a finger tip. | Blood lactate are measured before and acute after exercise sessions (within 2 min.), and in addition 24 hours post-exercise. |
| Change in sarcoidosis related fatigue |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Siri Skumlien, PhD | LHL Helse | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| LHL-klinikkene Glittre | Hakadal | 1485 | Norway |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D012507 | Sarcoidosis |
| D005221 | Fatigue |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006968 | Hypersensitivity, Delayed |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Endurance exercise training | Other | Two different endurance exercise training protocols will be compared; one exercise sessions is interval training with high intensity (85-95% of HRmax) versus one of moderate intensity (70-75% of HRmax) with longer duration. |
|
Assessed by the Fatigue Assessment Scale (FAS) |
| Measured first day and last day of a 4-week exercise based pulmonary rehabilitation |
| Change in metabolic and ventilatory variables from CPET | Ratio ventilation/carbon dioxide output (VE/VCO2) | Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation |
| Change in metabolic and ventilatory variables from CPET | Ventilatory (anaerobic) threshold (VT, %) | Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation |
| Change in maximal oxygen uptake | Maximal oxygen uptake (VO2, mL/min) | Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |