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The aim of this study was to evaluate collagen turnover in patients with multiple hernias
Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multiple hernia group | Males undergoing at least three repairs of abdominal wall hernias at three different anatomic locations. Collagen turnover is analysed. |
| |
| Control group | Males without any history or presence of hernias |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collagen turnover | Other | Type IV and V collagen synthesis and breakdown |
|
| Measure | Description | Time Frame |
|---|---|---|
| Type IV and V collagen synthesis and breakdown | Products from type IV and V collagen synthesis and breakdown are measured in serum. with ELISA from Nordic Bioscience A/S, Herlev, Denmark. Specifically, the biomarker for type IV collagen synthesis (P4NP) and breakdown (C4M), and for type V collagen synthesis (P5CP) and breakdown (C5M) was measured. The concentration unit for all parameters is ng/ml. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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Males with multiple hernias wer identified from the Danish Hernia Database. The control group were recruited from hospital staff.
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| Name | Affiliation | Role |
|---|---|---|
| Lars N Jorgensen, MD | Bispebjerg Hospital, Dept. of Surgery | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bispebjerg Hospital | Copenhagen | NV | DK-2400 | Denmark |
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| ID | Term |
|---|---|
| D046449 | Hernia, Abdominal |
| ID | Term |
|---|---|
| D006547 | Hernia |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Venous blood