Probiotics Effect on Glucose and Lipid Metabolism and Gut Microbiota in Patients With Obesity

Probiotics Effect on Glucose and Lipid Metabolism and Gut Microbiota in Patients With Obesity: a Randomized, Double-blind Controlled Trial

The purpose of this study is to determine whether the probiotics will be effective in the treatment of obesity

This study aims to evaluate the effect of probiotics on the improvement of glucose and lipid metabolism, as well as the gut microbiota.Baseline, 1 month and 3 months data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical practice for obesity patients.

Inclusion Criteria:

1. Age 15-60 years
2. BMI≥28.0kg/m2
3. Agree to cooperate in the trial
4. Provision of written informed consent

Exclusion Criteria:

1. With chronic gastrointestinal diseases, severe immune deficiency, lactose intolerance
2. Diabetes
3. Use antibiotics, bacteriostatic agents (eg berberine), lipid-lowering drugs, antacids, H2 Blockers, proton pump inhibitors, corticosteroids or sex hormones
4. Use any probiotics in the last 3 months
5. Allergic constitution
6. Participating in any other clinical trials
7. Was not able to insist until the end
8. Pregnant and lactating women