Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome

Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome

Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome. The purpose of this study is to describe the frequency of asynchronies (ineffective efforts and double triggering) in these group and evaluate potential risk factors and prognosis implications.

Major patient-ventilator asynchronies have been described during assisted mechanical ventilation in different settings. Few studies have evaluated double cycling in ARDS patient. No clear predictors of this finding beside low tidal volume have been found, and clinical outcome implications have not been addressed. This study has 3 main objectives: evaluate the frequency of double cycling and ineffective efforts, seek for potential predictors and clinical outcomes related to asynchronies. Subjects with less than 72 hours of mechanical ventilation due to ARDS will be recruited. Thirty minutes of mechanical ventilation will be recorded and automatically analyzed with a custom-made program to detect asynchronies. A blood sample will be drawn to measure inflammatory and lung tissue damage biomarkers. Clinical and outcome data will be recorded.

Inclusion Criteria:

• Acute Respiratory Distress Syndrome according to Berlin definition
• Intubation and mechanical ventilation within 72 hours of inclusion

Exclusion Criteria:

• Known severe neuromuscular disease
• Continuous neuromuscular blocking agents infusion