Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients

The Impact of Optimized Caloric-proteic Nutrition on Clinical Outcome and Physical Component Summary (PCS) of Quality of Life in Septic and Septic Shock Patients

In this pilot randomized prospective controlled trial the investigators intend to compare the use of a nutritional therapy based on caloric intake determined by indirect calorimetry and high protein intake with nutritional regimen based on 25 Kcal / kg / day and protein intake usually recommended for critically ill patients (1.4 to 1.5 grams / kg / day of protein).

Inclusion Criteria:

• Patients admitted to the ICU with sepsis and septic shock according to 3rd International Sepsis Consensus Conference Definitions for sepsis and septic shock
• Mechanically ventilated
• Expected length of stay in ICU ≥ 4 days
• Written informed consent obtained from authorized surrogates

Exclusion Criteria:

• Pregnancy
• Requirement for inspired oxygen content (FIO2) > 0.60
• High output bronchopleural fistula