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Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on postural control
Baseline measurements including the assessment of the center of pressure during 30s, the cerebral oxygen saturation and a sharpened Romberg test will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the base camp of the Atacama Large Millimeter/Submillimeter Array (ALMA) telescope station located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 8 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing testing as described above at the first and the last day at 5050m. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 8 day altitude sojourn participants will return to the Santiago area (520 m) for a 6 day recovery period.
A second altitude sojourn with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Altitude exposure | Experimental | Acute high altitude exposure followed by 8 day acclimatization and reexposure for 8 days after 6 days at low altitude |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| altitude exposure | Other | altitude exposure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Center of pressure path length measured by Wii-balance board | Changes in center of pressure path length during the 2 sojourns at 5050 m and compared to lowland. | Low altitude sojourn at 520 m; first sojourn at 5050 m Day 2, 7; second sojourn at 5050 m Day 2, 7 |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral tissue oxygen saturation measured by near infrared spectroscopy | Changes in cerebral oxygen saturation during the 2 sojourns at 5050 m and compared to lowland. | Low altitude sojourn at 520 m; first sojourn at 5050 m Day 2, 7; second sojourn at 5050 m Day 2, 7 |
| Postural stability measured by sharpened Romberg-test and heel-to-toe walk |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Konrad E Bloch, MD | University of Zurich | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Zurich | Zurich | 8091 | Switzerland |
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| ID | Term |
|---|---|
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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Changes in postural stability during the 2 sojourns at 5050 m and compared to lowland. |
| Low altitude sojourn at 520 m; first sojourn at 5050 m Day 2, 7; second sojourn at 5050 m Day 2, 7 |