Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy

Efficacy of Single-cycle Remote Ischemic Pre/Post-conditioning, for Prevention of Contrast-induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Coronary Angiography or Coronary Angioplasty

This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning for prevention of contrast-induced acute kidney injury in patient undergoing coronary angiography and angioplasty

randomized controlled trial

Inclusion Criteria:

• The patient have indication for coronary angiography or angioplasty.
• Impaired renal function with reduced eGFR < 60 ml/min/1.73 m2 by CKD-EPI equation.
• Written informed consent.

Exclusion Criteria:

• History of contrast allergy.
• The patient had end-stage renal failure with the need for hemodialysis.
• The patient take medications that affect the kidneys function within 48 hours before study.
• The patient had acute kidney injury from any cause.
• The patient was received contrast media within 2 weeks before study.
• The patient had cardiac arrest or shock.
• The patient had peripheral arterial disease (PAD)
• Pregnancy
• Refused to study